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Finding hidden treasures in old drugs: the challenges and importance of licensing generics

2017; Elsevier BV; Volume: 23; Issue: 1 Linguagem: Inglês

10.1016/j.drudis.2017.08.008

1878-5832

Melek Simsek, Berrie Meijer, Adriaan A. van Bodegraven, Nanne K.H. de Boer, Chris J. Mulder,

Health Systems, Economic Evaluations, Quality of Life

Identifying new indications for existing drugs creates new therapeutic options while bypassing much of the costs and time involved with bringing a new drug to market. The rediscovery of a generic drug, however, is a challenging pursuit because there is no formal regulatory approach and a lack of economic interest by pharmaceutical companies. This played a part in the re-registration of thioguanine as a rescue drug for the treatment of patients with inflammatory bowel disease in The Netherlands. In this article, we aim to underline the importance of drug rediscovery, the difficulties of this procedure in Europe and we attempt to suggest conceivable solutions.