Portal de Periódicos da CAPES

Antioxidant Therapeutic Strategies for Cardiovascular Conditions Associated with Oxidative Stress

2017; Multidisciplinary Digital Publishing Institute; Volume: 9; Issue: 9 Linguagem: Inglês

10.3390/nu9090966

2072-6643

Jorge G. Farías, Víctor M Molina, Rodrigo Carrasco, Andrea Zepeda, Elías Figueroa, Pablo Letelier, Rodrigo L. Castillo,

Chemotherapy-induced cardiotoxicity and mitigation

Oxidative stress (OS) refers to the imbalance between the generation of reactive oxygen species (ROS) and the ability to scavenge these ROS by endogenous antioxidant systems, where ROS overwhelms the antioxidant capacity. Excessive presence of ROS results in irreversible damage to cell membranes, DNA, and other cellular structures by oxidizing lipids, proteins, and nucleic acids. Oxidative stress plays a crucial role in the pathogenesis of cardiovascular diseases related to hypoxia, cardiotoxicity and ischemia–reperfusion. Here, we describe the participation of OS in the pathophysiology of cardiovascular conditions such as myocardial infarction, anthracycline cardiotoxicity and congenital heart disease. This review focuses on the different clinical events where redox factors and OS are related to cardiovascular pathophysiology, giving to support for novel pharmacological therapies such as omega 3 fatty acids, non-selective betablockers and microRNAs.