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Risk factors for increased duration of untreated psychosis. Results from the FACE-SZ dataset

2017; Elsevier BV; Volume: 195; Linguagem: Inglês

10.1016/j.schres.2017.08.058

1573-2509

Guillaume Fond, Laurent Boyer, M. Andrianarisoa, O. Godin, L. Brunel, E. Bulzacka, Nathalie Coulon, P.M. Llorca, Fabrice Berna, Bruno Aouizerate, Delphine Capdevielle, Thierry d’Amato, Caroline Dubertret, Julien Dubreucq, Catherine Faget, Franck Gabayet, Jasmina Mallet, D. Misdrahi, Romain Rey, Raphaëlle Richieri, Paul Roux, C. Passerieux, A. Schandrin, Anne-Marie Tronche, Pierre Vidailhet, Marion Leboyer, F. Schürhoff, M. Andrianarisoa, Bruno Aouizerate, Fabrice Berna, O. Blanc, L. Brunel, E. Bulzacka, Delphine Capdevielle, I. Chereau-Boudet, G. Chesnoy-Servanin, Jean‐Marie Danion, Thierry d’Amato, A. Deloge, C. Delorme, H. Denizot, Romain Rey, Caroline Dubertret, Julien Dubreucq, Catherine Faget, C. Fluttaz, Guillaume Fond, S. Fonteneau, Franck Gabayet, E. Giraud-Baro, Marie‐Christine Hardy‐Baylé, D. Lacelle, C. Lançon, H. Laouamri, Marion Leboyer, T. Le Gloahec, Y. Le Strat, P.M. Llorca, Jasmina Mallet, E. Metairie, D. Misdrahi, Isabelle Offerlin-Meyer, C. Passerieux, P. Peri, S. Pires, C. Portalier, Romain Rey, C. Roman, M. Sebilleau, A. Schandrin, F. Schürhoff, A. Tessier, Anne-Marie Tronche, Mathieu Urbach, F. Vaillant, A. Véhier, Pierre Vidailhet, Eduardo Martínez‐Vila, H. Yazbek, A. Zinetti-Bertschy,

Tryptophan and brain disorders

Reducing the duration of untreated psychosis (DUP) may improve the prognosis of schizophrenia. This study investigated the prevalence, and associated risk factors, of long DUP in a large, non-selected sample of community-dwelling schizophrenia patients (SZ).478 community-dwelling stable SZ participants (122 women and 356 men; mean age 32.37±9.86years) were recruited between 2010 and 2016. The mean retrospective DUP was evaluated from both patient and family reports, as well as hospital/psychiatrists records. Long DUP was defined as >2years.The mean DUP was 1.5years. 80 participants (16.7%) had a DUP>2years. In multivariate analyses, after adjustment for sex, education level, history of childhood trauma and history of maternal schizophrenia or bipolar disorder, long DUP was associated with a younger age of illness onset (19.3±6.67years vs. 22.0±6.51years, adjusted odd ratio aOR=0.91, 95%CI [0.86; 0.97], p=0.003) and cannabis use disorder (20.0% vs. 10.3%, aOR=2.41, 95%CI [1.14-5.09], p=0.02).A high proportion of SZ patients still have a long DUP. The present results suggest that illness onset before age 19years and cannabis use are associated with long DUP in schizophrenia patients. Early psychosis detection programs should prioritize the targeting of these populations.