Hypoplastic Left Heart Syndrome With Intact or Restrictive Atrial Septum
2017; Lippincott Williams & Wilkins; Volume: 136; Issue: 14 Linguagem: Inglês
10.1161/circulationaha.116.025873
ISSN1524-4539
AutoresDavid Jantzen, Anita J. Moon‐Grady, Shaine A. Morris, Aimee K. Armstrong, Christoph Berg, Joanna Szymkiewicz‐Dangel, Carlen G. Fifer, Michele A. Frommelt, U. Gembruch, Ulrike Herberg, Edgar Jaeggi, Eftichia V. Kontopoulos, Audrey C. Marshall, Owen Miller, Renate Oberhoffer, Dick Oepkes, Carlos Augusto Cardoso Pedra, Simone Pedra, Fabio Peralta, Rubén A. Quintero, Greg Ryan, Sarah Gelehrter,
Tópico(s)Congenital heart defects research
ResumoHomeCirculationVol. 136, No. 14Hypoplastic Left Heart Syndrome With Intact or Restrictive Atrial Septum Free AccessLetterPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissionsDownload Articles + Supplements ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toSupplemental MaterialFree AccessLetterPDF/EPUBHypoplastic Left Heart Syndrome With Intact or Restrictive Atrial SeptumA Report From the International Fetal Cardiac Intervention Registry David W. Jantzen, MD, Anita J. Moon-Grady, MD, Shaine A. Morris, MD, MPH, Aimee K. Armstrong, MD, Christoph Berg, MD, Joanna Dangel, MD, PhD, Carlen G. Fifer, MD, Michele Frommelt, MD, Ulrich Gembruch, MD, Ulrike Herberg, MD, Edgar Jaeggi, MD, Eftichia V. Kontopoulos, MD, PhD, Audrey C. Marshall, MD, Owen Miller, Renate Oberhoffer, MD, PhD, Dick Oepkes, MD, PhD, Carlos A. Pedra, MD, PhD, Simone R. Pedra, MD, PhD, Fabio Peralta, MD, Ruben A. Quintero, MD, Greg Ryan, MB and Sarah K. Gelehrter, MD David W. JantzenDavid W. Jantzen From C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (D.W.J., C.G.F., S.K.G.); University of California–San Francisco (A.J.M.-G.); Baylor College of Medicine, Houston, TX (S.A.M.); Nationwide Children’s Hospital, Columbus, OH (A.K.A.); University of Bonn, Germany (C.B., U.H.); Perinatal Cardiology Clinic, Medical University of Warsaw, Poland (J.D.); Children’s Hospital of Wisconsin, Milwaukee (M.F.); University Hospital Bonn, Germany (U.G.); Hospital for Sick Children, Toronto, Ontario, Canada (E.J.); Florida International University, Miami (E.V.K., R.A.Q.); Boston Children’s Hospital, MA (A.C.M.); Evelina London Children’s Hospital, United Kingdom (O.M.); Technische Universität München, Germany (R.O.); Leiden University Medical Center, Netherlands (D.O.); Hospital do Coração, São Paolo, Brazil (C.A.P., S.R.P., F.P.); and Mount Sinai Hospital, Toronto, Ontario, Canada (G.R.). Search for more papers by this author , Anita J. Moon-GradyAnita J. Moon-Grady From C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (D.W.J., C.G.F., S.K.G.); University of California–San Francisco (A.J.M.-G.); Baylor College of Medicine, Houston, TX (S.A.M.); Nationwide Children’s Hospital, Columbus, OH (A.K.A.); University of Bonn, Germany (C.B., U.H.); Perinatal Cardiology Clinic, Medical University of Warsaw, Poland (J.D.); Children’s Hospital of Wisconsin, Milwaukee (M.F.); University Hospital Bonn, Germany (U.G.); Hospital for Sick Children, Toronto, Ontario, Canada (E.J.); Florida International University, Miami (E.V.K., R.A.Q.); Boston Children’s Hospital, MA (A.C.M.); Evelina London Children’s Hospital, United Kingdom (O.M.); Technische Universität München, Germany (R.O.); Leiden University Medical Center, Netherlands (D.O.); Hospital do Coração, São Paolo, Brazil (C.A.P., S.R.P., F.P.); and Mount Sinai Hospital, Toronto, Ontario, Canada (G.R.). Search for more papers by this author , Shaine A. MorrisShaine A. Morris From C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (D.W.J., C.G.F., S.K.G.); University of California–San Francisco (A.J.M.-G.); Baylor College of Medicine, Houston, TX (S.A.M.); Nationwide Children’s Hospital, Columbus, OH (A.K.A.); University of Bonn, Germany (C.B., U.H.); Perinatal Cardiology Clinic, Medical University of Warsaw, Poland (J.D.); Children’s Hospital of Wisconsin, Milwaukee (M.F.); University Hospital Bonn, Germany (U.G.); Hospital for Sick Children, Toronto, Ontario, Canada (E.J.); Florida International University, Miami (E.V.K., R.A.Q.); Boston Children’s Hospital, MA (A.C.M.); Evelina London Children’s Hospital, United Kingdom (O.M.); Technische Universität München, Germany (R.O.); Leiden University Medical Center, Netherlands (D.O.); Hospital do Coração, São Paolo, Brazil (C.A.P., S.R.P., F.P.); and Mount Sinai Hospital, Toronto, Ontario, Canada (G.R.). Search for more papers by this author , Aimee K. ArmstrongAimee K. Armstrong From C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (D.W.J., C.G.F., S.K.G.); University of California–San Francisco (A.J.M.-G.); Baylor College of Medicine, Houston, TX (S.A.M.); Nationwide Children’s Hospital, Columbus, OH (A.K.A.); University of Bonn, Germany (C.B., U.H.); Perinatal Cardiology Clinic, Medical University of Warsaw, Poland (J.D.); Children’s Hospital of Wisconsin, Milwaukee (M.F.); University Hospital Bonn, Germany (U.G.); Hospital for Sick Children, Toronto, Ontario, Canada (E.J.); Florida International University, Miami (E.V.K., R.A.Q.); Boston Children’s Hospital, MA (A.C.M.); Evelina London Children’s Hospital, United Kingdom (O.M.); Technische Universität München, Germany (R.O.); Leiden University Medical Center, Netherlands (D.O.); Hospital do Coração, São Paolo, Brazil (C.A.P., S.R.P., F.P.); and Mount Sinai Hospital, Toronto, Ontario, Canada (G.R.). Search for more papers by this author , Christoph BergChristoph Berg From C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (D.W.J., C.G.F., S.K.G.); University of California–San Francisco (A.J.M.-G.); Baylor College of Medicine, Houston, TX (S.A.M.); Nationwide Children’s Hospital, Columbus, OH (A.K.A.); University of Bonn, Germany (C.B., U.H.); Perinatal Cardiology Clinic, Medical University of Warsaw, Poland (J.D.); Children’s Hospital of Wisconsin, Milwaukee (M.F.); University Hospital Bonn, Germany (U.G.); Hospital for Sick Children, Toronto, Ontario, Canada (E.J.); Florida International University, Miami (E.V.K., R.A.Q.); Boston Children’s Hospital, MA (A.C.M.); Evelina London Children’s Hospital, United Kingdom (O.M.); Technische Universität München, Germany (R.O.); Leiden University Medical Center, Netherlands (D.O.); Hospital do Coração, São Paolo, Brazil (C.A.P., S.R.P., F.P.); and Mount Sinai Hospital, Toronto, Ontario, Canada (G.R.). Search for more papers by this author , Joanna DangelJoanna Dangel From C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (D.W.J., C.G.F., S.K.G.); University of California–San Francisco (A.J.M.-G.); Baylor College of Medicine, Houston, TX (S.A.M.); Nationwide Children’s Hospital, Columbus, OH (A.K.A.); University of Bonn, Germany (C.B., U.H.); Perinatal Cardiology Clinic, Medical University of Warsaw, Poland (J.D.); Children’s Hospital of Wisconsin, Milwaukee (M.F.); University Hospital Bonn, Germany (U.G.); Hospital for Sick Children, Toronto, Ontario, Canada (E.J.); Florida International University, Miami (E.V.K., R.A.Q.); Boston Children’s Hospital, MA (A.C.M.); Evelina London Children’s Hospital, United Kingdom (O.M.); Technische Universität München, Germany (R.O.); Leiden University Medical Center, Netherlands (D.O.); Hospital do Coração, São Paolo, Brazil (C.A.P., S.R.P., F.P.); and Mount Sinai Hospital, Toronto, Ontario, Canada (G.R.). Search for more papers by this author , Carlen G. FiferCarlen G. Fifer From C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (D.W.J., C.G.F., S.K.G.); University of California–San Francisco (A.J.M.-G.); Baylor College of Medicine, Houston, TX (S.A.M.); Nationwide Children’s Hospital, Columbus, OH (A.K.A.); University of Bonn, Germany (C.B., U.H.); Perinatal Cardiology Clinic, Medical University of Warsaw, Poland (J.D.); Children’s Hospital of Wisconsin, Milwaukee (M.F.); University Hospital Bonn, Germany (U.G.); Hospital for Sick Children, Toronto, Ontario, Canada (E.J.); Florida International University, Miami (E.V.K., R.A.Q.); Boston Children’s Hospital, MA (A.C.M.); Evelina London Children’s Hospital, United Kingdom (O.M.); Technische Universität München, Germany (R.O.); Leiden University Medical Center, Netherlands (D.O.); Hospital do Coração, São Paolo, Brazil (C.A.P., S.R.P., F.P.); and Mount Sinai Hospital, Toronto, Ontario, Canada (G.R.). Search for more papers by this author , Michele FrommeltMichele Frommelt From C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (D.W.J., C.G.F., S.K.G.); University of California–San Francisco (A.J.M.-G.); Baylor College of Medicine, Houston, TX (S.A.M.); Nationwide Children’s Hospital, Columbus, OH (A.K.A.); University of Bonn, Germany (C.B., U.H.); Perinatal Cardiology Clinic, Medical University of Warsaw, Poland (J.D.); Children’s Hospital of Wisconsin, Milwaukee (M.F.); University Hospital Bonn, Germany (U.G.); Hospital for Sick Children, Toronto, Ontario, Canada (E.J.); Florida International University, Miami (E.V.K., R.A.Q.); Boston Children’s Hospital, MA (A.C.M.); Evelina London Children’s Hospital, United Kingdom (O.M.); Technische Universität München, Germany (R.O.); Leiden University Medical Center, Netherlands (D.O.); Hospital do Coração, São Paolo, Brazil (C.A.P., S.R.P., F.P.); and Mount Sinai Hospital, Toronto, Ontario, Canada (G.R.). Search for more papers by this author , Ulrich GembruchUlrich Gembruch From C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (D.W.J., C.G.F., S.K.G.); University of California–San Francisco (A.J.M.-G.); Baylor College of Medicine, Houston, TX (S.A.M.); Nationwide Children’s Hospital, Columbus, OH (A.K.A.); University of Bonn, Germany (C.B., U.H.); Perinatal Cardiology Clinic, Medical University of Warsaw, Poland (J.D.); Children’s Hospital of Wisconsin, Milwaukee (M.F.); University Hospital Bonn, Germany (U.G.); Hospital for Sick Children, Toronto, Ontario, Canada (E.J.); Florida International University, Miami (E.V.K., R.A.Q.); Boston Children’s Hospital, MA (A.C.M.); Evelina London Children’s Hospital, United Kingdom (O.M.); Technische Universität München, Germany (R.O.); Leiden University Medical Center, Netherlands (D.O.); Hospital do Coração, São Paolo, Brazil (C.A.P., S.R.P., F.P.); and Mount Sinai Hospital, Toronto, Ontario, Canada (G.R.). Search for more papers by this author , Ulrike HerbergUlrike Herberg From C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (D.W.J., C.G.F., S.K.G.); University of California–San Francisco (A.J.M.-G.); Baylor College of Medicine, Houston, TX (S.A.M.); Nationwide Children’s Hospital, Columbus, OH (A.K.A.); University of Bonn, Germany (C.B., U.H.); Perinatal Cardiology Clinic, Medical University of Warsaw, Poland (J.D.); Children’s Hospital of Wisconsin, Milwaukee (M.F.); University Hospital Bonn, Germany (U.G.); Hospital for Sick Children, Toronto, Ontario, Canada (E.J.); Florida International University, Miami (E.V.K., R.A.Q.); Boston Children’s Hospital, MA (A.C.M.); Evelina London Children’s Hospital, United Kingdom (O.M.); Technische Universität München, Germany (R.O.); Leiden University Medical Center, Netherlands (D.O.); Hospital do Coração, São Paolo, Brazil (C.A.P., S.R.P., F.P.); and Mount Sinai Hospital, Toronto, Ontario, Canada (G.R.). Search for more papers by this author , Edgar JaeggiEdgar Jaeggi From C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (D.W.J., C.G.F., S.K.G.); University of California–San Francisco (A.J.M.-G.); Baylor College of Medicine, Houston, TX (S.A.M.); Nationwide Children’s Hospital, Columbus, OH (A.K.A.); University of Bonn, Germany (C.B., U.H.); Perinatal Cardiology Clinic, Medical University of Warsaw, Poland (J.D.); Children’s Hospital of Wisconsin, Milwaukee (M.F.); University Hospital Bonn, Germany (U.G.); Hospital for Sick Children, Toronto, Ontario, Canada (E.J.); Florida International University, Miami (E.V.K., R.A.Q.); Boston Children’s Hospital, MA (A.C.M.); Evelina London Children’s Hospital, United Kingdom (O.M.); Technische Universität München, Germany (R.O.); Leiden University Medical Center, Netherlands (D.O.); Hospital do Coração, São Paolo, Brazil (C.A.P., S.R.P., F.P.); and Mount Sinai Hospital, Toronto, Ontario, Canada (G.R.). Search for more papers by this author , Eftichia V. KontopoulosEftichia V. Kontopoulos From C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (D.W.J., C.G.F., S.K.G.); University of California–San Francisco (A.J.M.-G.); Baylor College of Medicine, Houston, TX (S.A.M.); Nationwide Children’s Hospital, Columbus, OH (A.K.A.); University of Bonn, Germany (C.B., U.H.); Perinatal Cardiology Clinic, Medical University of Warsaw, Poland (J.D.); Children’s Hospital of Wisconsin, Milwaukee (M.F.); University Hospital Bonn, Germany (U.G.); Hospital for Sick Children, Toronto, Ontario, Canada (E.J.); Florida International University, Miami (E.V.K., R.A.Q.); Boston Children’s Hospital, MA (A.C.M.); Evelina London Children’s Hospital, United Kingdom (O.M.); Technische Universität München, Germany (R.O.); Leiden University Medical Center, Netherlands (D.O.); Hospital do Coração, São Paolo, Brazil (C.A.P., S.R.P., F.P.); and Mount Sinai Hospital, Toronto, Ontario, Canada (G.R.). Search for more papers by this author , Audrey C. MarshallAudrey C. Marshall From C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (D.W.J., C.G.F., S.K.G.); University of California–San Francisco (A.J.M.-G.); Baylor College of Medicine, Houston, TX (S.A.M.); Nationwide Children’s Hospital, Columbus, OH (A.K.A.); University of Bonn, Germany (C.B., U.H.); Perinatal Cardiology Clinic, Medical University of Warsaw, Poland (J.D.); Children’s Hospital of Wisconsin, Milwaukee (M.F.); University Hospital Bonn, Germany (U.G.); Hospital for Sick Children, Toronto, Ontario, Canada (E.J.); Florida International University, Miami (E.V.K., R.A.Q.); Boston Children’s Hospital, MA (A.C.M.); Evelina London Children’s Hospital, United Kingdom (O.M.); Technische Universität München, Germany (R.O.); Leiden University Medical Center, Netherlands (D.O.); Hospital do Coração, São Paolo, Brazil (C.A.P., S.R.P., F.P.); and Mount Sinai Hospital, Toronto, Ontario, Canada (G.R.). Search for more papers by this author , Owen MillerOwen Miller From C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (D.W.J., C.G.F., S.K.G.); University of California–San Francisco (A.J.M.-G.); Baylor College of Medicine, Houston, TX (S.A.M.); Nationwide Children’s Hospital, Columbus, OH (A.K.A.); University of Bonn, Germany (C.B., U.H.); Perinatal Cardiology Clinic, Medical University of Warsaw, Poland (J.D.); Children’s Hospital of Wisconsin, Milwaukee (M.F.); University Hospital Bonn, Germany (U.G.); Hospital for Sick Children, Toronto, Ontario, Canada (E.J.); Florida International University, Miami (E.V.K., R.A.Q.); Boston Children’s Hospital, MA (A.C.M.); Evelina London Children’s Hospital, United Kingdom (O.M.); Technische Universität München, Germany (R.O.); Leiden University Medical Center, Netherlands (D.O.); Hospital do Coração, São Paolo, Brazil (C.A.P., S.R.P., F.P.); and Mount Sinai Hospital, Toronto, Ontario, Canada (G.R.). Search for more papers by this author , Renate OberhofferRenate Oberhoffer From C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (D.W.J., C.G.F., S.K.G.); University of California–San Francisco (A.J.M.-G.); Baylor College of Medicine, Houston, TX (S.A.M.); Nationwide Children’s Hospital, Columbus, OH (A.K.A.); University of Bonn, Germany (C.B., U.H.); Perinatal Cardiology Clinic, Medical University of Warsaw, Poland (J.D.); Children’s Hospital of Wisconsin, Milwaukee (M.F.); University Hospital Bonn, Germany (U.G.); Hospital for Sick Children, Toronto, Ontario, Canada (E.J.); Florida International University, Miami (E.V.K., R.A.Q.); Boston Children’s Hospital, MA (A.C.M.); Evelina London Children’s Hospital, United Kingdom (O.M.); Technische Universität München, Germany (R.O.); Leiden University Medical Center, Netherlands (D.O.); Hospital do Coração, São Paolo, Brazil (C.A.P., S.R.P., F.P.); and Mount Sinai Hospital, Toronto, Ontario, Canada (G.R.). Search for more papers by this author , Dick OepkesDick Oepkes From C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (D.W.J., C.G.F., S.K.G.); University of California–San Francisco (A.J.M.-G.); Baylor College of Medicine, Houston, TX (S.A.M.); Nationwide Children’s Hospital, Columbus, OH (A.K.A.); University of Bonn, Germany (C.B., U.H.); Perinatal Cardiology Clinic, Medical University of Warsaw, Poland (J.D.); Children’s Hospital of Wisconsin, Milwaukee (M.F.); University Hospital Bonn, Germany (U.G.); Hospital for Sick Children, Toronto, Ontario, Canada (E.J.); Florida International University, Miami (E.V.K., R.A.Q.); Boston Children’s Hospital, MA (A.C.M.); Evelina London Children’s Hospital, United Kingdom (O.M.); Technische Universität München, Germany (R.O.); Leiden University Medical Center, Netherlands (D.O.); Hospital do Coração, São Paolo, Brazil (C.A.P., S.R.P., F.P.); and Mount Sinai Hospital, Toronto, Ontario, Canada (G.R.). Search for more papers by this author , Carlos A. PedraCarlos A. Pedra From C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (D.W.J., C.G.F., S.K.G.); University of California–San Francisco (A.J.M.-G.); Baylor College of Medicine, Houston, TX (S.A.M.); Nationwide Children’s Hospital, Columbus, OH (A.K.A.); University of Bonn, Germany (C.B., U.H.); Perinatal Cardiology Clinic, Medical University of Warsaw, Poland (J.D.); Children’s Hospital of Wisconsin, Milwaukee (M.F.); University Hospital Bonn, Germany (U.G.); Hospital for Sick Children, Toronto, Ontario, Canada (E.J.); Florida International University, Miami (E.V.K., R.A.Q.); Boston Children’s Hospital, MA (A.C.M.); Evelina London Children’s Hospital, United Kingdom (O.M.); Technische Universität München, Germany (R.O.); Leiden University Medical Center, Netherlands (D.O.); Hospital do Coração, São Paolo, Brazil (C.A.P., S.R.P., F.P.); and Mount Sinai Hospital, Toronto, Ontario, Canada (G.R.). Search for more papers by this author , Simone R. PedraSimone R. Pedra From C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (D.W.J., C.G.F., S.K.G.); University of California–San Francisco (A.J.M.-G.); Baylor College of Medicine, Houston, TX (S.A.M.); Nationwide Children’s Hospital, Columbus, OH (A.K.A.); University of Bonn, Germany (C.B., U.H.); Perinatal Cardiology Clinic, Medical University of Warsaw, Poland (J.D.); Children’s Hospital of Wisconsin, Milwaukee (M.F.); University Hospital Bonn, Germany (U.G.); Hospital for Sick Children, Toronto, Ontario, Canada (E.J.); Florida International University, Miami (E.V.K., R.A.Q.); Boston Children’s Hospital, MA (A.C.M.); Evelina London Children’s Hospital, United Kingdom (O.M.); Technische Universität München, Germany (R.O.); Leiden University Medical Center, Netherlands (D.O.); Hospital do Coração, São Paolo, Brazil (C.A.P., S.R.P., F.P.); and Mount Sinai Hospital, Toronto, Ontario, Canada (G.R.). Search for more papers by this author , Fabio PeraltaFabio Peralta From C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (D.W.J., C.G.F., S.K.G.); University of California–San Francisco (A.J.M.-G.); Baylor College of Medicine, Houston, TX (S.A.M.); Nationwide Children’s Hospital, Columbus, OH (A.K.A.); University of Bonn, Germany (C.B., U.H.); Perinatal Cardiology Clinic, Medical University of Warsaw, Poland (J.D.); Children’s Hospital of Wisconsin, Milwaukee (M.F.); University Hospital Bonn, Germany (U.G.); Hospital for Sick Children, Toronto, Ontario, Canada (E.J.); Florida International University, Miami (E.V.K., R.A.Q.); Boston Children’s Hospital, MA (A.C.M.); Evelina London Children’s Hospital, United Kingdom (O.M.); Technische Universität München, Germany (R.O.); Leiden University Medical Center, Netherlands (D.O.); Hospital do Coração, São Paolo, Brazil (C.A.P., S.R.P., F.P.); and Mount Sinai Hospital, Toronto, Ontario, Canada (G.R.). Search for more papers by this author , Ruben A. QuinteroRuben A. Quintero From C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (D.W.J., C.G.F., S.K.G.); University of California–San Francisco (A.J.M.-G.); Baylor College of Medicine, Houston, TX (S.A.M.); Nationwide Children’s Hospital, Columbus, OH (A.K.A.); University of Bonn, Germany (C.B., U.H.); Perinatal Cardiology Clinic, Medical University of Warsaw, Poland (J.D.); Children’s Hospital of Wisconsin, Milwaukee (M.F.); University Hospital Bonn, Germany (U.G.); Hospital for Sick Children, Toronto, Ontario, Canada (E.J.); Florida International University, Miami (E.V.K., R.A.Q.); Boston Children’s Hospital, MA (A.C.M.); Evelina London Children’s Hospital, United Kingdom (O.M.); Technische Universität München, Germany (R.O.); Leiden University Medical Center, Netherlands (D.O.); Hospital do Coração, São Paolo, Brazil (C.A.P., S.R.P., F.P.); and Mount Sinai Hospital, Toronto, Ontario, Canada (G.R.). Search for more papers by this author , Greg RyanGreg Ryan From C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (D.W.J., C.G.F., S.K.G.); University of California–San Francisco (A.J.M.-G.); Baylor College of Medicine, Houston, TX (S.A.M.); Nationwide Children’s Hospital, Columbus, OH (A.K.A.); University of Bonn, Germany (C.B., U.H.); Perinatal Cardiology Clinic, Medical University of Warsaw, Poland (J.D.); Children’s Hospital of Wisconsin, Milwaukee (M.F.); University Hospital Bonn, Germany (U.G.); Hospital for Sick Children, Toronto, Ontario, Canada (E.J.); Florida International University, Miami (E.V.K., R.A.Q.); Boston Children’s Hospital, MA (A.C.M.); Evelina London Children’s Hospital, United Kingdom (O.M.); Technische Universität München, Germany (R.O.); Leiden University Medical Center, Netherlands (D.O.); Hospital do Coração, São Paolo, Brazil (C.A.P., S.R.P., F.P.); and Mount Sinai Hospital, Toronto, Ontario, Canada (G.R.). Search for more papers by this author and Sarah K. GelehrterSarah K. Gelehrter From C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (D.W.J., C.G.F., S.K.G.); University of California–San Francisco (A.J.M.-G.); Baylor College of Medicine, Houston, TX (S.A.M.); Nationwide Children’s Hospital, Columbus, OH (A.K.A.); University of Bonn, Germany (C.B., U.H.); Perinatal Cardiology Clinic, Medical University of Warsaw, Poland (J.D.); Children’s Hospital of Wisconsin, Milwaukee (M.F.); University Hospital Bonn, Germany (U.G.); Hospital for Sick Children, Toronto, Ontario, Canada (E.J.); Florida International University, Miami (E.V.K., R.A.Q.); Boston Children’s Hospital, MA (A.C.M.); Evelina London Children’s Hospital, United Kingdom (O.M.); Technische Universität München, Germany (R.O.); Leiden University Medical Center, Netherlands (D.O.); Hospital do Coração, São Paolo, Brazil (C.A.P., S.R.P., F.P.); and Mount Sinai Hospital, Toronto, Ontario, Canada (G.R.). Search for more papers by this author Originally published1 Sep 2017https://doi.org/10.1161/CIRCULATIONAHA.116.025873Circulation. 2017;136:1346–1349Other version(s) of this articleYou are viewing the most recent version of this article. Previous versions: January 1, 2017: Previous Version 1 Infants with hypoplastic left heart syndrome and an intact or highly restrictive atrial septum (HLHS-IAS) represent a high-risk subset. Fetal cardiac intervention (FCI) for fetuses with HLHS-IAS has been reported in single-institution series as a therapy that may improve outcomes. This study uses the International Fetal Cardiac Intervention Registry (IFCIR) to examine fetal and maternal characteristics and pregnancy and neonatal outcome data for FCI in this population.For this descriptive analysis, the IFCIR was queried for fetuses with HLHS-IAS evaluated between 2001 and March 2015 for possible FCI and felt to be candidates at the referral center by a variety of published criteria including foramen ovale (FO) size, shunt flow direction across the FO, and pulmonary venous Doppler flow patterns. It includes those who were determined not to be candidates because of other fetal noncardiac conditions, maternal conditions, or maternal preferences, or because FCI was not performed at the participating institution. Further details on the methodology of the IFCIR registry are found in the initial report.1Participating IFCIR member sites obtained local institutional review board and ethics board approval or a waiver, as governed by applicable local standards. Forty-eight previously published patients (15 non-FCI, 33 FCI including 17 septoplasties and 16 stents) from the 2015 initial IFCIR report were included, of whom 18 FCI patients had also been reported in single-center publications.1–5The results are summarized in Tables 1 and 2. Data from 13 institutions were submitted; 89 maternal–fetal dyads with fetal HLHS-IAS were identified. We excluded 17 non-FCI patients who terminated the pregnancy. Of the remaining 72 cases of HLHS-IAS, 47 dyads from 8 sites underwent FCI: 27 with atrial septoplasty alone (atrial perforation/balloon dilation) and 20 with atrial septal stent placement. There were 36 (77%) procedural successes with a higher proportion of septoplasties being successful, although this did not reach statistical significance (13/20=65% stent versus 23/27=85% septoplasty, Fisher exact P=0.16). Although there were no maternal complications, fetal complications were common, and procedure-related fetal demise occurred in 6 (13%). Cesarean delivery, planned immediate postnatal intervention, restrictive FO, and neonatal resuscitation were less common in those who underwent procedurally successful FCI in comparison with those with unsuccessful FCI or no FCI. Only 18/41=45% of all FCI livebirths had a clinically nonrestrictive FO at delivery. One successful stent terminated pregnancy. There was a trend toward stents performing better than septoplasties in maintaining a nonrestrictive FO at delivery after procedural success (9/12=75% versus 9/23=39%, Fisher exact P=0.075), and discharge survival was 7/12=58% with successful stents. However, overall discharge survival was poor (35%), and there was no difference between groups, either overall (34% FCI versus 36% no FCI) or with procedural success (44% successful FCI versus 33% unsuccessful or no FCI). Postdischarge follow-up data were available in 18/24=75% of the survivor cohort, with 59% 1-year actuarial survival in the FCI fetuses with a nonrestrictive FO at birth versus 19% in non FCI fetuses (log rank P=0.03).Table 1. Procedural and Outcome Registry* Data for Hypoplastic Left Heart Syndrome with Restrictive or Intact Atrial Septum, Fetal Cardiac Intervention and Non-InterventionAll Patients (N=72)No FCI† (N=25)FCI (N=47)P ValuePregnancy Outcome, n (%) Procedural death+TOP7 (10)06+1 (15)0.57 (livebirths) Preterm (<37wks)16 (22)5 (20)11 (23) Term49 (68)20 (80)29 (62)Pregnancy complication reported, n (%)9 (13)3 (12)6 (13)1.00Type of delivery‡, livebirths§, n (%) Cesarean‖31/44 (70)18/21 (86)13/23 (57)0.049 IMPACT or EXIT17/44 (39)14/21 (67)3/23 (13) 1 Balloon used, n (%)3 (11)4 (20)0.44Laser, n (%)1 (4)1 (5)1.00> 1 Cardiac puncture, n (%)6 (22)6 (30)1.00Procedural complications,
Referência(s)