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MicroRNAs in lung cancer

2017; Impact Journals LLC; Volume: 8; Issue: 46 Linguagem: Inglês

10.18632/oncotarget.20955

1949-2553

Diana Castro, Márcia Zabdiele Moreira, Alexandra Gouveia, Daniel Humberto Pozza, Ramon Andrade de Mello,

Circular RNAs in diseases

// Diana Castro 1 , Márcia Moreira 1 , Alexandra Monteiro Gouveia 1, 2, 3 , Daniel Humberto Pozza 1, 3 and Ramon Andrade De Mello 4, 5, 6 1 Department of Experimental Biology, Faculty of Medicine, University of Porto, Porto, Portugal 2 Institute for Cellular and Molecular Biology (IBMC), Institute for Health Innovation, University of Porto, Porto, Portugal 3 Faculty of Nutrition and Food Sciences, University of Porto, Porto, Portugal 4 Department of Biomedical Sciences and Medicine, University of Algarve, Faro, Portugal 5 Department of Medicine, Faculty of Medicine, University of Porto, Porto, Portugal 6 Cearense School of Oncology, Ceará Cancer Institute, Fortaleza, Brazil Correspondence to: Ramon Andrade De Mello, email: ramondemello@doctors.org.uk Keywords: microRNAs, lung cancer, inflammation, epithelial mesenchymal transition, interleukin 1 Received: April 12, 2017 Accepted: August 26, 2017 Published: September 16, 2017 ABSTRACT Lung cancer (LC) is a serious public health problem responsible for the majority of cancer deaths and comorbidities in developed countries. Tobacco smoking is considered the main risk factor for LC; however, only a few smokers will be affected by this cancer. Current screening methods are focused on identifying the early stages of this malignancy. Thus, new data concerning the roles of microRNA alterations in inflammation, epithelial-mesenchymal transition and lung disease have increased hope about LC pathogenesis, diagnosis, treatment and prognosis. MicroRNA mechanisms include angiogenesis promotion, cell cycle regulation by modulating cellular proliferation and apoptosis, and migration and invasion inhibition. In this context, this manuscript reviews the current information about many important microRNAs as they relate to the initiation and progression of LC.