A review article on biosimilar infliximab SB2 in the treatment of rheumatoid arthritis
2017; Future Medicine; Volume: 9; Issue: 14 Linguagem: Inglês
10.2217/imt-2017-0068
ISSN1750-7448
AutoresSalvatore Bellinvia, Madiha Ashraf, Riccardo Polosa, Christopher J Edwards,
Tópico(s)CAR-T cell therapy research
ResumoTNF inhibition has had a major impact as an approach for treating rheumatoid arthritis and a series of biologic agents directed against TNF have been developed for clinical use. Infliximab, a chimeric monoclonal antibody against soluble and membrane-bound TNF-α, was the biopharmaceutical to lead this 'biologics revolution'. However, with expiration of patent protection of the originator medicinal product, biosimilar versions of infliximab have been developed through biosimilarity studies and randomized controlled trials aiming to assess pharmacokinetic, pharmacodynamic and clinical equivalence to their originator (reference product) in patients with moderate-to-severe disease activity. This review summarizes the clinical development of SB2, a biosimilar of infliximab, in rheumatoid arthritis.
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