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Uptake of AV-1451 in meningiomas

2017; Springer Nature; Volume: 31; Issue: 10 Linguagem: Inglês

10.1007/s12149-017-1205-0

1864-6433

Tyler J. Bruinsma, Derek R. Johnson, Ping Fang, Matthew L. Senjem, Keith A. Josephs, Jennifer L. Whitwell, Bradley F. Boeve, Mukesh K. Pandey, Kejal Kantarci, David T. Jones, Prashanthi Vemuri, Melissa E. Murray, Jonathan Graff‐Radford, Christopher G. Schwarz, David S. Knopman, Ronald C. Petersen, Clifford R. Jack, Val J. Lowe,

Neurofibromatosis and Schwannoma Cases

AV-1451 is an imaging agent labeled with the positron-emitting radiolabel Fluorine-18. 18F-AV-1451 binds paired helical filament tau (PHF-tau), a pathology related to Alzheimer’s disease. In our study of AV-1451 uptake in the brains of cognitively normal subjects, we noted a case of a meningioma with visually significant uptake of AV-1451. We initiated the present retrospective study to further examine cases of meningioma that underwent AV-1451 imaging. We searched the patient records of 650 patients who had undergone AV-1451 at our institution for the keyword “meningioma” to identify potential cases. PET/CT and MRI results were visually reviewed and semi-quantitative analysis of PET was performed. A paired student’s t test was run between background and tumor standard uptake values. Fisher’s exact test was used to examine the association between AV-1451 uptake and presence of calcifications on CT. We identified 12 cases of meningioma, 58% (7/12) of which demonstrated uptake greater than background using both visual analysis and tumor-to-normal cortex ratios (T/N + 1.90 ± 0.83). The paired student’s t test revealed no statistically significant difference between background and tumor standard uptake values (p = 0.09); however, cases with a T/N ratio greater than one showed statistically higher uptake in tumor tissue (p = 0.01). A significant association was noted between AV-1451 uptake and presence of calcifications (p = 0.01). AV-1451 PET imaging should be reviewed concurrently with anatomic imaging to prevent misleading interpretations of PHF-tau distribution due to meningiomas.