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Hypolipidemic activity of P-methoxycinnamic diester (PCO-C) isolated from Copernicia prunífera against Triton WR-1339 and hyperlipidemic diet in mice

2017; Elsevier BV; Volume: 56; Linguagem: Inglês

10.1016/j.etap.2017.09.015

1872-7077

Antônio Carlos Vasconcelos Arruda Filho, Paula Alves Salmito Rodrigues, Stephen Rathinaraj Benjamin, Raquel Teixeira Terceiro Paim, Marcelo Oliveira Holanda, José Ytalo Gomes da Silva, Tomer Milo, Ícaro Gusmão Pinto Vieira, Maria Goretti Rodrigues de Queiroz, Maria Izabel Florindo Guedes,

Natural product bioactivities and synthesis

Carnauba wax is extracted from the leaves of the Copernicia prunífera and contains approximately 80% of esters in its composition. The purpose of the present study was evaluate the hypolipidemic effect of p-methoxycinnamic diesters (PCO-C) extracted from Copernicia prunífera in a model of acute and chronic dyslipidemia in mice. The levels of total cholesterol and triglycerides were significantly reduced plasma levels in PCO-C at the dose of 100mg/kg in a model of acute and chronic dyslipidemia. Histological studies showed that PCO-C has no hepatotoxic effect and reduces hepatic steatosis in animals that consumed hyperlipidemic ration. Thus, it was concluded that PCO-C isolated from Copernicia Prunifera was effective in reducing total cholesterol and triglyceride levels in both dyslipidemia induction models. The finding indicates that PCO-C might be beneficial in treatment of hyperlipidemia and atherosclerosis.