Emergence of Ceftolozane-Tazobactam-Resistant Pseudomonas aeruginosa during Treatment Is Mediated by a Single AmpC Structural Mutation
2017; American Society for Microbiology; Volume: 61; Issue: 12 Linguagem: Inglês
10.1128/aac.01183-17
ISSN1098-6596
AutoresShawn H. MacVane, Ruchi Pandey, Lisa L. Steed, Barry N. Kreiswirth, Liang Chen,
Tópico(s)Antibiotics Pharmacokinetics and Efficacy
ResumoCeftolozane-tazobactam is a cephalosporin-β-lactamase inhibitor combination that exhibits potent in vitro activity against Pseudomonas aeruginosa, including strains that are resistant to other β-lactams. The emergence of ceftolozane-tazobactam resistance among clinical isolates of P. aeruginosa has rarely been described. Here we characterized ceftolozane-tazobactam-resistant P. aeruginosa strains recovered from a patient who was treated with this agent for 6 weeks for a recurrent wound infection. The results showed that the resistance was mediated by a single AmpC structural mutation.
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