RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg
2017; American Association for the Advancement of Science; Volume: 9; Issue: 409 Linguagem: Inglês
10.1126/scitranslmed.aan0241
ISSN1946-6242
AutoresChristine I. Wooddell, Man‐Fung Yuen, Henry Lik‐Yuen Chan, Robert G. Gish, Stephen Locarnini, Deborah Chavez, Carlo Ferrari, Bruce D. Given, James Hamilton, Steven B. Kanner, Ching‐Lung Lai, Johnson Y.N. Lau, Thomas Schluep, Zhao Xu, Robert E. Lanford, David L. Lewis,
Tópico(s)Immunotherapy and Immune Responses
ResumoThe hepatitis B virus surface antigen, key to maintaining chronic infection, is expressed from viral DNA integrated into the host chromosome.
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