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Injury mechanisms in acute intracerebral hemorrhage

2017; Elsevier BV; Volume: 134; Linguagem: Inglês

10.1016/j.neuropharm.2017.09.033

1873-7064

David Wilkinson, Aditya S. Pandey, B. Gregory Thompson, Richard F. Keep, Ya Hua, Guohua Xi,

Neurosurgical Procedures and Complications

Intracerebral hemorrhage (ICH) is the most common hemorrhagic stroke subtype, and rates are increasing with an aging population. Despite an increase in research and trials of therapies for ICH, mortality remains high and no interventional therapy has been demonstrated to improve outcomes. We review known mechanisms of injury, recent clinical trial results, and newly discovered signaling pathways involved in hematoma clearance. Enthusiasm remains high for methods of minimally invasive clot removal as well as pharmacologic strategies to improve recovery after ICH, both of which are currently being evaluated in clinical trials. This article is part of the Special Issue entitled 'Cerebral Ischemia'.