Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study
2017; American Diabetes Association; Volume: 66; Issue: 12 Linguagem: Inglês
10.2337/db17-0398
ISSN1939-327X
AutoresLucia Sobrin, Yong He Chong, Qiao Fan, Alfred Tau Liang Gan, Lynn K. Stanwyck, Georgia Kaidonis, Jamie E. Craig, Jihye Kim, Wen‐Ling Liao, Yu‐Chuen Huang, Wen‐Jane Lee, Yi‐Jen Hung, Xiuqing Guo, Yang Hai, Eli Ipp, Samuela Pollack, Heather Hancock, Alkes L. Price, Alan D. Penman, Paul Mitchell, Gerald Liew, Albert V. Smith, Vilmundur Guðnason, Gavin Siew Wei Tan, Barbara E.K. Klein, Jane Z. Kuo, Xiaohui Li, Mark Christiansen, Bruce M. Psaty, Kevin Sandow, Richard A. Jensen, Ronald Klein, Mary Frances Cotch, Jie Jin Wang, Yucheng Jia, Ching J. Chen, Yii‐Der Ida Chen, Jerome I. Rotter, Fuu‐Jen Tsai, Craig L. Hanis, Kathryn P. Burdon, Tien Yin Wong, Ching‐Yu Cheng, Cassandra N. Spracklen, Peng Chen, Young Jin Kim, Xu Wang, Hui Cai, Shengxu Li, Jirong Long, Ying Wu, Ya Xing Wang, Fumihiko Takeuchi, Jer‐Yuarn Wu, Keum Ji Jung, Cheng Hu, Koichi Akiyama, Yonghong Zhang, Sanghoon Moon, Todd A. Johnson, Huaixing Li, Rajkumar Dorajoo, Meian He, Maren E. Cannon, Tamara S. Roman, Elias Salfati, Keng‐Hung Lin, Wayne H.-H. Sheu, Devin Absher, Linda S. Adair, Themistocles L. Assimes, Tin Aung, Qiuyin Cai, Li-Ching Chang, Chien-Hsiun Chen, Li-Hsin Chien, Lee‐Ming Chuang, Shu‐Chun Chuang, Shufa Du, Cathy S.J. Fann, Alan B. Feranil, Yechiel Friedlander, Penny Gordon‐Larsen, Dongfeng Gu, Lixuan Gui, Zhirong Guo, Chew‐Kiat Heng, James E. Hixson, Xuhong Hou, Chao A. Hsiung, Yao Hu, Mi Yeong Hwang, Chii‐Min Hwu, Masato Isono, Jyh‐Ming Jimmy Juang, Chiea Chuen Khor, Yun Kyoung Kim, Woon‐Puay Koh, Michiaki Kubo, I‐Te Lee, Sunju Lee, Kae‐Woei Liang, Blanche Lim, Sing‐Hui Lim, Jianjun Liu, Toru Nabika, Wen‐Harn Pan, Hao Peng, Thomas Quertermous, Charumathi Sabanayagam, Jinxiu Shi, Liang Sun, Pok Chien Tan, Shu-Pei Tan, Kent D. Taylor, Yik-Ying Teo, Sue‐Anne Toh, Tatsuhiko Tsunoda, Rob M. van Dam, Aili Wang, Feijie Wang, Jie Wang, Wen Bin Wei, Yong‐Bing Xiang, Jie Yao, Jian‐Min Yuan, Rong Zhang, Wanting Zhao, Stephen S. Rich, Tzung‐Dau Wang, Tangchun Wu, Lin Xu, Bok‐Ghee Han, Toshihiro Tanaka, Yoon Shin Cho, Tomohiro Katsuya, Weiping Jia, Sun Ha Jee, Yuan-Tsong Chen, Norihiro Kato, Jost B. Jonas, Xiao-Ou Shu, Jiang He, Wei Zheng, Wei Huang, Bong-Jo Kim, E Shyong Tai, Karen L. Mohlke, Xueling Sim,
Tópico(s)Retinal Diseases and Treatments
ResumoResults from observational studies examining dyslipidemia as a risk factor for diabetic retinopathy (DR) have been inconsistent. We evaluated the causal relationship between plasma lipids and DR using a Mendelian randomization approach. We pooled genome-wide association studies summary statistics from 18 studies for two DR phenotypes: any DR (
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