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BIBTEX RIS

Sentinel lymph node biopsy versus observation in thick melanoma: A multicenter propensity score matching study

2017; Wiley; Volume: 142; Issue: 3 Linguagem: Inglês

10.1002/ijc.31078

ISSN

1097-0215

Autores

Aram Boada, A. Tejera‐Vaquerizo, Simone Ribero, Susana Puig, D. Moreno‐Ramírez, M.Á. Descalzo, Maria Teresa Fierro, Pietro Quaglino, Cristina Carrera, Josep Malvehy, Sergi Vidal‐Sicart, Antoni Bennássar, R. Rull, Llúcia Alós, Celia Requena, Isidro Bolumar, V. Través, Ángel Plá, María Teresa Fernández‐Figueras, Carlos Ferrándiz, Iciar Pascual Miguel, José Luís Manzano, Marina Sánchez‐Lucas, Pol Giménez‐Xavier, L. Ferrándiz, Eduardo Nagore,

Tópico(s)

Nonmelanoma Skin Cancer Studies

Resumo

The clinical value of sentinel lymph node (SLN) biopsy in thick melanoma patients (Breslow >4 mm) has not been sufficiently studied. The aim of the study is to evaluate whether SLN biopsy increases survival in patients with thick cutaneous melanoma, and, as a secondary objective, to investigate correlations between survival and lymph node status. We included 1,211 consecutive patients with thick melanomas (>4 mm) registered in the participating hospitals' melanoma databases between 1997 and 2015. Median follow-up was 40 months. Of these patients, 752 were matched into pairs by propensity scores based on sex, age, tumor location, histologic features of melanoma, year of diagnosis, hospital and adjuvant interferon therapy. The SLN biopsy vs. observation was associated with better DFS [adjusted hazard ratio (AHR), 0.74; 95% confidence interval (CI) 0.61-0.90); p = 0.002] and OS (AHR, 0.75; 95% CI, 0.60-0.94; p = 0.013) but not MSS (AHR, 0.84; 95% CI, 0.65-1.08; p = 0.165). SLN-negative patients had better 5- and 10-year MSS compared with SLN-positive patients (65.4 vs. 51.9% and 48.3 vs. 38.8%; p = 0.01, respectively). As a conclusion, SLN biopsy was associated with better DFS but not MSS in thick melanoma patients after adjustment for classic prognostic factors. SLN biopsy is useful for stratifying these patients into different prognostic groups.

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