Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Brown Algae Padina sanctae-crucis Børgesen: A Potential Nutraceutical

2017; Multidisciplinary Digital Publishing Institute; Volume: 15; Issue: 10 Linguagem: Inglês

10.3390/md15100251

1660-3397

Raquel Bezerra de Sá de Sousa Nogueira, Anna Cláudia de Andrade Tomaz, D. C. N. P. Pessoa, Aline Silva Gomes Xavier, João Carlos Lima Rodrigues Pita, Marianna Vieira Sobral, Marcela Lins Cavalcanti de Pontes, Hilzeth Pessôa, Margareth de Fátima Formiga Melo Diniz, George Emmanuel Cavalcanti de Miranda, Maria Aparecida Ribeiro Vieira, Márcia Ortiz Mayo Marques, Maria Souza, Emídio Vasconcelos Leitão da Cunha,

Natural product bioactivities and synthesis

Padina sanctae-crucis Børgesen is distributed worldwide in tropical and subtropical seas; belongs to the Dictyotaceae family, and has proven to be an exceptional source of biologically active compounds. Four compounds were isolated and identified, namely: dolastane diterpene new for the genus Padina; phaeophytin and hidroxy-phaeophytin new for the family Dictyotaceae, and; mannitol first described in this species. Saturated fatty acids as compared to the percentages of unsaturated fatty acids were shown to be present in greater abundance. Palmitic and linolenic acid were the main saturated and unsaturated acids, respectively. Cytotoxic and antioxidant activities were evaluated using human erythrocytes. In vivo evaluations of acute toxicity and genotoxicity were performed in mice. Methanolic extract of P. sanctae-crucis presented antioxidant activity and did not induce cytotoxicity, genotoxicity or acute toxicity. Since Padina sanctae-crucis is already used as food, has essential fatty acids for the nutrition of mammals, does not present toxicity and has antioxidant activity, it can be considered as a potential nutraceutical.