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BIBTEX RIS

Method for identification of condition-associated public antigen receptor sequences

2018; eLife Sciences Publications Ltd; Volume: 7; Linguagem: Inglês

10.7554/elife.33050

ISSN

2050-084X

Autores

Mikhail V. Pogorelyy, Anastasia A. Minervina, Dmitriy M. Chudakov, Ilgar Z. Mamedov, Yuri B. Lebedev, Thierry Mora, Aleksandra M. Walczak,

Tópico(s)

T-cell and B-cell Immunology

Resumo

Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences. We developed a statistical framework for associating receptors to disease from only a small cohort of patients, with no need for a control cohort. Our method successfully identifies previously validated Cytomegalovirus and type 1 diabetes responsive receptors.

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