Produção Nacional
Revisado por pares
Protective effect of carvacrol on acetic acid-induced colitis
2017; Elsevier BV; Volume: 96; Linguagem: Inglês
10.1016/j.biopha.2017.10.017
ISSN1950-6007
AutoresMarília Trindade de Santana Souza, Daiane Franco Teixeira, Janaíne Prata de Oliveira, Alan Santos Oliveira, Lucindo José Quintans‐Júnior, Cristiane Bani Corrêa, Enilton A. Camargo,
Tópico(s)Moringa oleifera research and applications
ResumoThe pharmacological therapy for inflammatory bowel diseases continues to be problematic, and requires new alternative options. In this study, we tested the hypothesis that carvacrol (CAR), a phenolic monoterpene with anti-inflammatory and antioxidant activities, can treat experimental colitis in mice. C57BL/6 mice (n = 8/group) were subjected to intrarectal administration of acetic acid (5%) to induce colitis. Mice were pretreated with CAR (25, 50 or 100 mg/kg, p.o.) every 12 h for three days prior to the induction. Abdominal hyperalgesia, macroscopic and microscopic colon damage, myeloperoxidase (MPO) activity, tumor necrosis factor (TNF)-α and interleukin (IL)-1β levels, oxidative stress markers, and antioxidant enzyme activities were evaluated. Pretreatment with all doses of CAR significantly decreased abdominal hyperalgesia and colon MPO activity and TNF-α and IL-1β levels. A reduction in macroscopic and microscopic damage (p < 0.05) was observed at doses of 50 and 100 mg/kg CAR. Pretreatment with CAR significantly reduced lipid peroxidation (for all doses) and increased sulfhydryl groups (at 100 mg/kg). This effect was accompanied by a significant increase in catalase, superoxide dismutase, and glutathione peroxidase activities. These findings indicate that CAR protected mice from acetic acid-induced colitis by reducing inflammatory, nociceptive, and oxidative damages.
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