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Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study

2017; Elsevier BV; Volume: 28; Issue: 1 Linguagem: Inglês

10.1016/j.numecd.2017.10.004

1590-3729

Esther M. González‐Gil, Cristina Cadenas‐Sánchez, Javier Santabárbara, Gloria Bueno, Iris Iglesia, Marcela González‐Gross, Dénes Molnár, F. Gottrand, Stefaan De Henauw, Anthony Kafatos, K. Widhalm, Yannis Μanios, Alfonso Siani, Francisco J. Amaro‐Gahete, Azahara I. Rupérez, D. Cañada, Laura Censi, M. Kersting, Jean Dallongeville, Ascensión Marcos, Francisco B. Ortega, Luís A. Moreno, Luís A. Moreno, F. Gottrand, Stefaan De Henauw, Marcela González‐Gross, Chantal Gilbert, Anthony Kafatos, Christian Libersa, S Castello, M. Kersting, Michael Sjöstróm, Dénes Molnár, Jean Dallongeville, Gunnar Hall, Lea Maes, Luca Scalfi, P. Meléndez, Jesús Fleta, José A. Casajús, Gerardo Rodrı́guez, Concepción Tomás, M.I. Mesana, Germán Vicente‐Rodríguez, Adoración Villarroya, Carlos Martínez Gil, Ignacio Ara, J.F. Alvira, Gloria Bueno, A. Lázaro, O. Bueno, J.F. León, J. M. Garagorri, Manuel Bueno Sánchez, Idoia Labayen, Iris Iglesia, Silvia Bel Serrat, Luis A. Marco, Theodora Mouratidou, Alba M. Santaliestra-Pasías, Esther M. González‐Gil, Pilar De Miguel‐Etayo, Cristina Julián, María L. Miguel‐Berges, Isabel Iguacel, Ascensión Marcos, Julia Wärnberǵ, Esther Nova, Sonia Gómez, L. E. Díaz, Javier Romeo, Ana M. Veses, Belén Zapatera, T. Pozo, David Martínez, Laurent Béghin, F. Gottrand, Cătălina Iliescu Gheorghiu, J. Von Berlepsch, Wolfgang Sichert‐Hellert, E. Koeppen, Dénes Molnár, Éva Erhardt, Katalin Csernus, Katalin Török, Szilvia Bokor, Angster, Enikő Nagy, Orsolya Kovács, J. Répasi, C. Codrington, María Plada, Angeliki Papadaki, Katerina Sarri, A. Viskadourou, Christos Hatzis, Michael Kiriakakis, G. Tsibinos, Constantine Vardavas, M. Sbokos, E. Protoyeraki, Maria Fasoulaki, Peter Stehle, Klaus Pietrzik, C. Breidenassel, André Spinneker, J Al-Tahan, Miriam Segoviano, A. Berchtold, C. Bierschbach, E. Blatzheim, A. Schuch, P. Pickert, M.J. Castillo, Ángel Gutiérrez, F.B. Ortega, J.R. Ruiz, Enrique G. Artero, V. España, D. Jiménez-Pavón, Palma Chillón, Cristóbal Sánchez‐Muñoz, M. Cuenca, D. Arcella, Elena Azzini, E. Barrison, Noemi Bevilacqua, Pasquale Buonocore, Giovina Catasta, Laura Censi, Donatella Ciarapica, P. D'Acapito, M Ferrari, Myriam Galfo, Cinzia Le Donne, Catherine Leclercq, Giuseppe Maiani, Mauro Virgílio Gomes de Barros, Lorenza Mistura, A. Pasquali, Raffaela Piccinelli, A. Polito, Romana Roccaldo, Raffaella Spada, Stefania Sette, M. Zaccaria, Paola Vitaglione, Concetta Montagnese, Ilse De Bourdeaudhuij, T. De Vriendt, Christophe Matthys, Carine Vereecken, Mieke De Maeyer, Charlene Ottevaere, I. Huybrechts, K. Widhalm, K. Phillipp, S. Dietrich, K. Widhalm, K. Phillipp, Sabine Dietrich, Yannis Μanios, Evangelia Grammatikaki, Z. Bouloubasi, Tina Louisa Cook, S. Eleutheriou, O. Consta, George Moschonis, Ioanna Katsaroli, G. Kraniou, Στάλω Παπούτσου, D. Keke, Ioanna Petraki, Elena Bellou, Sofia Tanagra, K. Kallianoti, Dionysia Argyropoulou, Stamatoula Tsikrika, Christos Karaiskos, Aline Meirhaeghe, Aline Meirhaeghe, F.B. Ortega, María Hagströmer, Anita Hurtig Wennlöf, Lena Hällström, E. Patterson, Lydia Kwak, Nico Rizzo, J. Sánchez-Molero, E. Picó, María Ángeles Martínez Navarro, Blanca Viadel, J.E. Carreres, G. Merino, R. Sanjuán, M. Lorente, María‐José Sánchez, Sarah A. Thomas, E. Allchurch, P. Burgess, Annika Åström, A. Sverkén, A. Broberg, A. Masson, C. Lehoux, Paige Brabant, P. Pate, L. Fontaine, A. Sebok, Tünde Kuti, Adrienn Hegyi, Cristina A. Maldonado, Ana Llorente, Emilio García García, H. von Fircks, Marianne Lilja Hallberg, Maria Messerer, Mats Larsson, Helena Fredriksson, Viola Adamsson, I. Börjesson, L. Fernández, Laura Smillie, J. Wills, Raquel Pedrero‐Chamizo, A. Mélendez, Jara Valtueña, Ulrike Albers, Pedro J. Benito, J.J. Gómez Lorente, D. Cañada, A. Urzanqui, Rosa María Torres, Paloma Navarro,

Cardiovascular Disease and Adiposity

Background and aims Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabolic profile in European adolescents, considering BMI. Methods and results A total of 659 adolescents (295 boys) from a cross-sectional European study were included. Adolescents were classified by metabolic health based on age- and sex-specific cut-off points for glucose, blood pressure, triglycerides, high density cholesterol and BMI. C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin (IL-6), complement factors (C3, C4) and cell adhesion molecules were assessed. Results Metabolically abnormal (MA) adolescents had higher values of C3 (p < 0.001) and C4 (p = 0.032) compared to those metabolically healthy (MHy). C3 concentrations significantly increased with the deterioration of the metabolic health and BMI (p < 0.001). Adolescents with higher values of CRP had higher probability of being in the overweight/obese-MH group than those allocated in other categories. Finally, high C3 and C4 concentrations increased the probability of having an unfavorable metabolic/BMI status. Conclusions Metabolic/BMI status and inflammatory biomarkers are associated, being the CRP, C3 and C4 the most related inflammatory markers with this condition. C3 and C4 were associated with the cardio-metabolic health consistently.