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Evaluation of Antioxidant, Anti-Inflammatory, Antibacterial Activity and In Silico Molecular Docking Study of Pyrazole Curcumin Bisacetamide Analogs

2017; Wiley; Volume: 2; Issue: 28 Linguagem: Inglês

10.1002/slct.201701533

2365-6549

Govindharasu Banuppriya, Rajendran Sribalan, Vediappen Padmini,

Synthesis and Characterization of Heterocyclic Compounds

ChemistrySelectVolume 2, Issue 28 p. 9168-9173 Full Paper Evaluation of Antioxidant, Anti-Inflammatory, Antibacterial Activity and In Silico Molecular Docking Study of Pyrazole Curcumin Bisacetamide Analogs Govindharasu Banuppriya, Govindharasu Banuppriya Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, IndiaSearch for more papers by this authorRajendran Sribalan, Rajendran Sribalan Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, IndiaSearch for more papers by this authorDr. Vediappen Padmini, Corresponding Author Dr. Vediappen Padmini padimini_tamilenthi@yahoo.co.in Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, IndiaSearch for more papers by this author Govindharasu Banuppriya, Govindharasu Banuppriya Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, IndiaSearch for more papers by this authorRajendran Sribalan, Rajendran Sribalan Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, IndiaSearch for more papers by this authorDr. Vediappen Padmini, Corresponding Author Dr. Vediappen Padmini padimini_tamilenthi@yahoo.co.in Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, IndiaSearch for more papers by this author First published: 09 October 2017 https://doi.org/10.1002/slct.201701533Citations: 5Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract A series of pyrazole curcumin bisacetamides(4 a-l) were synthesized and studied their biological responses. These compounds have shown marvellous antioxidant and anti-inflammatory activities towards curcumin and standard drug. The compounds 4 d, 4 j, and 4 l, have shown better antibacterial activity. Further, the molecular docking studies revealed that the compounds 4 d and 4 l have shown better binding interaction with penicillin binding protein (PBP) via five hydrogen bond interactions. Abstract A series of pyrazole curcumin bisacetamides (4 a-l) were synthesized with excellent yield and in vitro antioxidant, anti-inflammatory and antibacterial activities were studied. These compounds have shown marvelous antioxidant and anti-inflammatory activities towards curcumin and standard drug. The compounds 4 d, 4 j, 4 l, have shown better antibacterial activity than ciprofloxacin and parent curcumin in both gram-positive and gram-negative bacterias. The compounds 4 j, 4 k, and 4 l have exhibited very good activity on methicillin-resistant staphylococcus aureus when compared to standard oxacillin and parent curcumin. Further, the molecular docking studies revealed that the compounds 4 d and 4 l have shown better binding interaction with penicillin binding protein via five hydrogen bond interactions. Conflict of interest The authors declare no conflict of interest. Citing Literature Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description slct201701533-sup-0001-misc_information.pdf905.2 KB Supplementary Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume2, Issue28September 29, 2017Pages 9168-9173 RelatedInformation