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Cerebrospinal fluid analysis and the determination of oligoclonal bands

2017; Springer Science+Business Media; Volume: 38; Issue: S2 Linguagem: Inglês

10.1007/s10072-017-3034-2

1590-3478

Matteo Gastaldi, Elisabetta Zardini, Rosaria Leante, Maddalena Ruggieri, Gianna Costa, Eleonora Cocco, Giovanna De Luca, Ivana Cataldo, Tiziana Biagioli, Clara Ballerini, Massimiliano Castellazzi, Enrico Fainardi, P Pettini, Mauro Zaffaroni, Debora Giunti, Elisabetta Capello, Gaetano Bernardi, Emilio Ciusani, Claudia Giannotta, Eduardo Nobile‐Orazio, Elena Bazzigaluppi, Gabriella Passerini, Roberta Bedin, Patrizia Sola, Rinaldo Brivio, Guido Cavaletti, Arianna Sala, Antonio Bertolotto, Gaetano Desina, Maurizio Leone, Sara Mariotto, Sérgio Ferrari, Andreina Paternoster, Davide Giavarina, Francesco Lolli, Diego Franciotta,

Neuroinflammation and Neurodegeneration Mechanisms

This document presents the guidelines for the cerebrospinal fluid (CSF) analysis and the determination of oligoclonal bands (OCBs) as pivotal tests in neuroinflammatory pathologies of the central nervous system. The guidelines have been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses. Essential clinical information on the pathologies in which the CSF analysis is indicated, and, particularly, on those characterized by the presence of OCBs in the intrathecal compartment, indications and limits of CSF analysis and OCB determination, instructions for result interpretation, and agreed laboratory protocols (Appendix) are reported for the communicative community of neurologists and clinical pathologists.