Produção Nacional
Revisado por pares
Neuropharmacological and acute toxicological evaluation of ethanolic extract of Allamanda cathartica L. flowers and plumieride
2017; Elsevier BV; Volume: 91; Linguagem: Inglês
10.1016/j.yrtph.2017.10.005
ISSN1096-0295
AutoresTiago José Bonomini, Iandra Holzmann, Liliani Carolini Thiesen, Eduarda Fratoni, Ana Flavia Fischer Muller, Ruth Meri Lucinda-Silva, Rosendo A. Yunes, Ângela Malheiros, Ana Elisa Gonçalves, Ana Paula Dalmagro, Kathryn Ana Bortolini Simão da Silva, Márcia María de Souza, José Roberto Santin,
Tópico(s)Natural Antidiabetic Agents Studies
ResumoPsychiatric diseases affect more than 350 million people all over the world, and medicinal plants have been considered the basis for pharmacological research. The study investigates the anticonvulsant and antidepressant-like activities and acute toxicological effects of ethanolic extract of Allamanda cathartica flowers, and plumieride. The extract was analyzed by HPLC and plumieride was isolated. Toxicity studies were carried out on females Wistar rats (2000 mg/kg). Toxicity was evaluated by measuring biochemical parameters and conducting histopathological analysis. For pharmacological evaluation different doses of the extract (100, 150 and 300 mg/kg, p.o.) and plumieride (0.5, 1 and 2 μg/kg, i.p.) were administered before the Forced-Swimming Test (FST), pentylenetetrazole seizure test (PTZT) or Tail-Suspension Test (TST) in mice. Furthermore, hemolytic activity, cytotoxicity and micronucleus test were performed. In addition, mutagenicity and reproductive/developmental toxicity were estimated by TEST-software analysis. Data show that both treatments induce significant antidepressive-like effect in FST and TST, but not anticonvulsant effect. The effect of plumieride last up to 4 h after treatment. No signs of toxicity, mutagenicity, cytotoxicity or hemolytic activity were observed. The TEST-software demonstrated that plumieride present reproductive/developmental toxicity. Together, the data obtained show that the flowers extract and plumieride present antidepressant-like effect and did not present signals of acute toxicity.
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