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Liquid biopsy in the diagnosis of HPV DNA in breast lesions

2017; Future Medicine; Volume: 13; Issue: 2 Linguagem: Inglês

10.2217/fmb-2017-0145

1746-0921

Sabrina De Carolis, A Pellegrini, Donatella Santini, Claudio Ceccarelli, Antonio De Leo, Federica Alessandrini, Chiara Arienti, Sara Pignatta, Anna Tesei, Vilma Mantovani, Claudio Zamagni, Mario Taffurelli, Pasquale Sansone, Massimiliano Bonafé, Monica Cricca,

Viral-associated cancers and disorders

HPV DNA has never been investigated in nipple discharges (ND) and serum-derived extracellular vesicles, although its presence has been reported in ductal lavage fluids and blood specimens.We analyzed 50 ND, 22 serum-derived extracellular vesicles as well as 51 pathologic breast tissues for the presence of 16 HPV DNA types.We show that the presence of HPV DNA in the ND is predictive of HPV DNA-positive breast lesions and that HPV DNA is more represented in intraductal papillomas. We also show the presence of HPV DNA in the serum-derived extracellular vesicles.Our data supports the use of liquid biopsy to detect HPV DNA in breast pathology.