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Lactic Acid: No Longer an Inert and End-Product of Glycolysis

2017; American Physiological Society; Volume: 32; Issue: 6 Linguagem: Inglês

10.1152/physiol.00016.2017

1548-9213

Shiren Sun, Heng Li, Jianghua Chen, Qi Qian,

Mitochondrial Function and Pathology

For decades, lactic acid has been considered a dead-end product of glycolysis. Research in the last 20+ years has shown otherwise. Through its transporters (MCTs) and receptor (GPR81), lactic acid plays a key role in multiple cellular processes, including energy regulation, immune tolerance, memory formation, wound healing, ischemic tissue injury, and cancer growth and metastasis. We summarize key findings of lactic acid signaling, functions, and many remaining questions.