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NK cell recovery after haploidentical HSCT with posttransplant cyclophosphamide: dynamics and clinical implications

2017; Elsevier BV; Volume: 131; Issue: 2 Linguagem: Inglês

10.1182/blood-2017-05-780668

1528-0020

Antonio Russo, Giacomo Oliveira, Sofia Berglund, Raffaella Greco, Valentina Gambacorta, Nicoletta Cieri, Cristina Toffalori, Laura Zito, Francesca Lorentino, Simona Piemontese, Mara Morelli, Fabio Giglio, Andrea Assanelli, Maria Teresa Lupo Stanghellini, Chiara Bonini, Jacopo Peccatori, Fabio Ciceri, Leo Luznik, Luca Vago,

Polyomavirus and related diseases

Key Points Posttransplantation cyclophosphamide eliminates most mature donor NK cells infused with the graft, including alloreactive NK cells. High levels of serum interleukin-15 early after HSCT provide a favorable environment for adoptive infusion of mature donor NK cells.