Innate Immune Evasion Mediated by Flaviviridae Non-Structural Proteins
2017; Multidisciplinary Digital Publishing Institute; Volume: 9; Issue: 10 Linguagem: Inglês
10.3390/v9100291
ISSN1999-4915
AutoresShun Chen, Zhen Wu, Mingshu Wang, Anchun Cheng,
Tópico(s)Viral Infections and Vectors
ResumoFlaviviridae-caused diseases are a critical, emerging public health problem worldwide. Flaviviridae infections usually cause severe, acute or chronic diseases, such as liver damage and liver cancer resulting from a hepatitis C virus (HCV) infection and high fever and shock caused by yellow fever. Many researchers worldwide are investigating the mechanisms by which Flaviviridae cause severe diseases. Flaviviridae can interfere with the host’s innate immunity to achieve their purpose of proliferation. For instance, dengue virus (DENV) NS2A, NS2B3, NS4A, NS4B and NS5; HCV NS2, NS3, NS3/4A, NS4B and NS5A; and West Nile virus (WNV) NS1 and NS4B proteins are involved in immune evasion. This review discusses the interplay between viral non-structural Flaviviridae proteins and relevant host proteins, which leads to the suppression of the host’s innate antiviral immunity.
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