Targeting the renin-angiotensin system to improve cancer treatment: Implications for immunotherapy
2017; American Association for the Advancement of Science; Volume: 9; Issue: 410 Linguagem: Inglês
10.1126/scitranslmed.aan5616
ISSN1946-6242
AutoresMatthias Pinter, Rakesh K. Jain,
Tópico(s)Prostate Cancer Treatment and Research
ResumoRenin-angiotensin system (RAS) inhibitors (RASi)-widely prescribed for the treatment of cardiovascular diseases-have considerable potential in oncology. The RAS plays a crucial role in cancer biology and affects tumor growth and dissemination directly and indirectly by remodeling the tumor microenvironment. We review clinical data on the benefit of RASi in primary and metastatic tumors and propose that, by activating immunostimulatory pathways, these inhibitors can enhance immunotherapy of cancer.
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