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Cross-Sectional Epidemiological Analysis of the Nagahama Study for Correlates of Overactive Bladder: Genetic and Environmental Considerations

2017; Lippincott Williams & Wilkins; Volume: 199; Issue: 3 Linguagem: Inglês

10.1016/j.juro.2017.09.146

1527-3792

Satoshi Funada, Takahisa Kawaguchi, Naoki Terada, Hiromitsu Negoro, Yasuharu Tabara, Shinji Kosugi, Ryo Yamada, Takeo Nakayama, Shusuke Akamatsu, Koji Yoshimura, Fumihiko Matsuda, Osamu Ogawa,

Gastroesophageal reflux and treatments

No AccessJournal of UrologyAdult Urology1 Mar 2018Cross-Sectional Epidemiological Analysis of the Nagahama Study for Correlates of Overactive Bladder: Genetic and Environmental Considerations Satoshi Funada, Takahisa Kawaguchi, Naoki Terada, Hiromitsu Negoro, Yasuharu Tabara, Shinji Kosugi, Ryo Yamada, Takeo Nakayama, Shusuke Akamatsu, Koji Yoshimura, Fumihiko Matsuda, Osamu Ogawa, and Nagahama Study Group Satoshi FunadaSatoshi Funada Department of Urology, Kyoto University Hospital, Kyoto, Japan More articles by this author , Takahisa KawaguchiTakahisa Kawaguchi Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan More articles by this author , Naoki TeradaNaoki Terada Department of Urology, Kyoto University Hospital, Kyoto, Japan More articles by this author , Hiromitsu NegoroHiromitsu Negoro Department of Urology, Kyoto University Hospital, Kyoto, Japan More articles by this author , Yasuharu TabaraYasuharu Tabara Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan More articles by this author , Shinji KosugiShinji Kosugi Department of Medical Ethics and Medical Genetics, Kyoto University School of Public Health, Kyoto, Japan More articles by this author , Ryo YamadaRyo Yamada Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan More articles by this author , Takeo NakayamaTakeo Nakayama Department of Health Informatics, Kyoto University School of Public Health, Kyoto, Japan More articles by this author , Shusuke AkamatsuShusuke Akamatsu Department of Urology, Kyoto University Hospital, Kyoto, Japan More articles by this author , Koji YoshimuraKoji Yoshimura Department of Urology, Shizuoka General Hospital, Shizuoka, Japan More articles by this author , Fumihiko MatsudaFumihiko Matsuda Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan More articles by this author , Osamu OgawaOsamu Ogawa Department of Urology, Kyoto University Hospital, Kyoto, Japan More articles by this author , and Nagahama Study Group More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.09.146AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The prevalence of overactive bladder is increasing globally. It has a substantial impact on quality of life and represents a heavy economic burden. We evaluated the prevalence of overactive bladder in a Japanese population and analyzed whether genetic and environmental factors influence overactive bladder. Materials and Methods: This cross-sectional study was performed as part of the Nagahama cohort project. It comprised a questionnaire survey as well as anthropometric, physiological and biochemical measures, and genomic information on participants 30 to 74 years old in Nagahama, Japan. A genome-wide association study was performed in 4,645 participants, including 1,521 men and 3,124 women, using 99,059 single nucleotide polymorphisms. Univariate and multivariable logistic regression was done to analyze environmental factors associated with overactive bladder. Results: The prevalence of overactive bladder was 11.8%, including 15.3% in men and 10.1% in women, and it increased with age. We found no significant association between overactive bladder and any single nucleotide polymorphism in the genome-wide association study. However, in the multivariable logistic regression model overactive bladder was positively associated with environmental factors, including age, depression and the consumption of cake or Japanese confection. Conclusions: The prevalence of overactive bladder was greater in men than in women, especially among the elderly. Environmental factors rather than genetic variants more likely contribute to overactive bladder. References 1 : The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. Neurourol Urodyn2002; 21: 167. Google Scholar 2 : How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence study. BJU Int2001; 87: 760. 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Google Scholar © 2018 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byOmae K, Kurita N, Takeshima T, Naganuma T, Takahashi S, Yoshioka T, Ohnishi T, Ito F, Hamaguchi S and Fukuhara S (2020) Significance of Overactive Bladder as a Predictor of Falls in Community Dwelling Older Adults: 1-Year Followup of the Sukagawa StudyJournal of Urology, VOL. 205, NO. 1, (219-225), Online publication date: 1-Jan-2021.Funada S, Tabara Y, Setoh K, Negoro H, Akamatsu S, Yoshino T, Yoshimura K, Watanabe N, Furukawa T, Matsuda F and Ogawa O (2020) Impact of Nocturia on Mortality: The Nagahama StudyJournal of Urology, VOL. 204, NO. 5, (996-1002), Online publication date: 1-Nov-2020.Funada S, Tabara Y, Negoro H, Akamatsu S, Yoshino T, Yoshimura K, Watanabe N, A. Furukawa T, Matsuda F and Ogawa O (2019) Longitudinal Analysis of Bidirectional Relationships between Nocturia and Depressive Symptoms: The Nagahama StudyJournal of Urology, VOL. 203, NO. 5, (984-990), Online publication date: 1-May-2020.Fukunaga A, Kawaguchi T, Funada S, Yoshino T, Tabara Y, Matsuda F, Yoshimura K, Ogawa O and Negoro H (2019) Sleep Disturbance Worsens Lower Urinary Tract Symptoms: The Nagahama StudyJournal of Urology, VOL. 202, NO. 2, (354-354), Online publication date: 1-Aug-2019. Volume 199Issue 3March 2018Page: 774-778Supplementary Materials Advertisement Copyright & Permissions© 2018 by American Urological Association Education and Research, Inc.Keywordsurinary bladdersexoveractivegenome-wide association studyenvironmentJapanMetricsAuthor Information Satoshi Funada Department of Urology, Kyoto University Hospital, Kyoto, Japan More articles by this author Takahisa Kawaguchi Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan More articles by this author Naoki Terada Department of Urology, Kyoto University Hospital, Kyoto, Japan More articles by this author Hiromitsu Negoro Department of Urology, Kyoto University Hospital, Kyoto, Japan More articles by this author Yasuharu Tabara Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan More articles by this author Shinji Kosugi Department of Medical Ethics and Medical Genetics, Kyoto University School of Public Health, Kyoto, Japan More articles by this author Ryo Yamada Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan More articles by this author Takeo Nakayama Department of Health Informatics, Kyoto University School of Public Health, Kyoto, Japan More articles by this author Shusuke Akamatsu Department of Urology, Kyoto University Hospital, Kyoto, Japan More articles by this author Koji Yoshimura Department of Urology, Shizuoka General Hospital, Shizuoka, Japan More articles by this author Fumihiko Matsuda Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan More articles by this author Osamu Ogawa Department of Urology, Kyoto University Hospital, Kyoto, Japan More articles by this author Nagahama Study Group More articles by this author Expand All Advertisement PDF downloadLoading ...