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[P3–576]: VALIDITY AND RELIABILITY OF THE BRAZILIAN PORTUGUESE VERSION OF THE ANU‐ADRI

2017; Wiley; Volume: 13; Issue: 7S_Part_25 Linguagem: Inglês

10.1016/j.jalz.2017.06.1796

1552-5279

Marcus Kiiti Borges, Alessandro Jacinto Ferrari, Vanessa de Albuquerque Cítero,

Health Education and Validation

The ANU-ADRI is a self-report tool that assesses risk and protective factors for Alzheimer's disease focusing on the primary prevention (Figure 1). We aimed to validate a Brazilian Portuguese version of this instrument and to test its association with low levels of schooling in Brazil. In this longitudinal study, the sample was formed (n = 100) by two groups (A and B): each one with 50 patients assisted by GPs (general practitioners) or specialists in dementia (Figure 2). At the baseline, they were assessed by a sociodemographic questionnaire and clinical inventory. All participants were cognitively healthy after screening using the MMSE. The ANU-ADRI was applied at baseline (test) and until 1 week after the test (retest). The median age was 62 years similar to mean age. The intraclass correlation coefficient (ICC) was 0.912 (P < 0.001, CI95% = [0.872;0.940]). (Figure 3) shows that there was a correlation between the mean scores of the ANU-ADRI test and retest (r = 0.918, P < 0.001). The Bland-Altman plot for the two measurements of the ANU-ADRI score is shown in (Figure 4). We noted that in group A, the percentage of individuals with 12 years or more of schooling was lower than group B (P < 0.05). According to (Figure 5), the group A had higher scores of ANU-ADRI than those of group B (P = 0.021). Effect size using Cohen's (d) was 0.469 (IC95% = [0.070;0.865]). According to (Figure 6), there was a moderate negative linear relation between the ANU-ADRI and MEEM scores (r= -0.353, P < 0.001) indicating that higher the MMSE score, lower the ANU-ADRI score (= less risk to develop Alzheimer's disease). We have concluded that low levels of education are related to higher risk scores of the ANU-ADRI. This questionnaire is valid and reliable for use in Brazil. Risk and protective factors for AD (Source: adapted from Anstey et al.). *not considered in the ANU-ADRI Questionnaire. A flow diagram shows initial recruitment, the exclusions and the samples. CIND = Cognitive Impairment no Dementia; GPs = General Practitioners; CHC = Community Health Center; HIZA = ”Hospital do Idoso Zilda Arns”. ∗Dementia cases (were assessed and confirmed by experts: neurologists and psychiatrists). Dispersion plot of relationship between ANU-ADRI Test and Retest. Bland-Altman plot for the two measurements of the ANU-ADRI. 5% of observations were outside the agreement limits of 95% (-7.1; 9.6). Mean difference observed was 1.2 (Standard Deviation = 4.3). Mean scores ranged -12 to 46. Box - Plot of the ANU-ADRI by groups A and B. Dispersion plot of ANU-ADRI and MMSE scores.