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A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort

2017; Nature Portfolio; Volume: 7; Issue: 1 Linguagem: Inglês

10.1038/s41598-017-14020-9

2045-2322

Steve Pedrini, Veer Bala Gupta, Eugene Hone, James D. Doecke, Sid E. O’Bryant, Ian James, Ashley I. Bush, Christopher C. Rowe, Victor L. Villemagne, David Ames, Colin L. Masters, Ralph N. Martins, Greg Savage, Bill Wilson, Pierrick Bourgeat, Jürgen Fripp, Simon Gibson, Hugo Leroux, Simon McBride, Olivier Salvado, Michael Fenech, Maxime François, Mary Barnes, Jenalle E. Baker, Kevin J. Barnham, Shayne A. Bellingham, Julia Bomke, Sveltana Bozin Pejoska, Rachel F. Buckley, Lesley Cheng, Steven Collins, Ian Cooke, Elizabeth Cyarto, David Darby, Vincent Doré, Denise El-Sheikh, Noel G. Faux, Christopher Fowler, Karra Harrington, Andy Hill, Malcolm Horne, Gareth Jones, Adrian Kamer, Neil Killeen, Hannah Korrel, Fiona Lamb, Nicola T. Lautenschlager, Kate Lennon, Qiao‐Xin Li, Yen Ying Lim, Andrea Louey, Lance Macaulay, Lucy Mackintosh, Paul Maruff, Alissandra Mcilroy, Julie Nigro, Kayla Perez, Kelly K. Pertile, Carolina Restrepo, Bárbara Rita Cardoso, Alan Rembach, Blaine R. Roberts, Jo Robertson, Rebecca Rumble, Tim Ryan, Jack Sach, Brendan Silbert, Christine Thai, Brett Trounson, Irene Volitakis, Michael Vovos, Larry D. Ward, Andrew D. Watt, Rob Williams, Mark Woodward, Paul Yates, Fernanda Yevenes Ugarte, Ping Zhang, Sabine Bird, Belinda M. Brown, Samantha Burnham, Pratishtha Chatterjee, Kay L. Cox, Shane Fernandez, Binosha Fernando, Samantha L. Gardener, Simon M. Laws, Florence Lim, Lucy Lim, Michelle Tegg, Kathy Lucas, Georgia Martins, Tenielle Porter, Stephanie R. Rainey‐Smith, Mark Rodrigues, Kaikai Shen, Hamid R. Sohrabi, Kevin Taddei, Tania Taddei, Sherilyn Tan, Giuseppe Verdile, Michael Weinborn, Maree Farrow, Shaun Frost, David G. Hanson, Maryam Hor, Yogi Kanagasingam, Wayne R. Leifert, Linda J. Lockett, Malcolm Riley, I D Saunders, Philip Thomas,

Diabetes and associated disorders

Alzheimer's Disease (AD) is the most common form of dementia, characterised by extracellular amyloid deposition as plaques and intracellular neurofibrillary tangles of tau protein. As no current clinical test can diagnose individuals at risk of developing AD, the aim of this project is to evaluate a blood-based biomarker panel to identify individuals who carry this risk. We analysed the levels of 22 biomarkers in clinically classified healthy controls (HC), mild cognitive impairment (MCI) and Alzheimer's participants from the well characterised Australian Imaging, Biomarker and Lifestyle (AIBL) study of aging. High levels of IL-10 and IL-12/23p40 were significantly associated with amyloid deposition in HC, suggesting that these two biomarkers might be used to detect at risk individuals. Additionally, other biomarkers (Eotaxin-3, Leptin, PYY) exhibited altered levels in AD participants possessing the APOE ε4 allele. This suggests that the physiology of some potential biomarkers may be altered in AD due to the APOE ε4 allele, a major risk factor for AD. Taken together, these data highlight several potential biomarkers that can be used in a blood-based panel to allow earlier identification of individuals at risk of developing AD and/or early stage AD for which current therapies may be more beneficial.