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Conserved Oligomeric Golgi and Neuronal Vesicular Trafficking

2017; Springer Science+Business Media; Linguagem: Inglês

10.1007/164_2017_65

1865-0325

Leslie K. Climer, Rachel Hendrix, Vladimir Lupashin,

Endoplasmic Reticulum Stress and Disease

The conserved oligomeric Golgi (COG) complex is an evolutionary conserved multi-subunit vesicle tethering complex essential for the majority of Golgi apparatus functions: protein and lipid glycosylation and protein sorting. COG is present in neuronal cells, but the repertoire of COG function in different Golgi-like compartments is an enigma. Defects in COG subunits cause alteration of Golgi morphology, protein trafficking, and glycosylation resulting in human congenital disorders of glycosylation (CDG) type II. In this review we summarize and critically analyze recent advances in the function of Golgi and Golgi-like compartments in neuronal cells and functions and dysfunctions of the COG complex and its partner proteins.