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<b>GASTRIN-RELEASING PEPTIDE (GRP)/BOMBESIN-LIKE IMMUNOREACTIVITY IN THE NEURONS AND PARANEURONS OF THE GUT AND </b><b>LUNG </b>

1983; Allied Academies; Volume: 4; Issue: 1 Linguagem: Inglês

10.2220/biomedres.4.93

1880-313X

Toshihiko Iwanaga,

Biotin and Related Studies

Gastrin-releasing peptide (GRP)/bombesin-like immunoreactivities in the gut and lung were investigated with an immunocytochemical method using antisera showing different specificity for GRP-related peptides and bombesin.GRP-like, but not bombesin-like, immunoreactivity in the gut of birds and frogs was contained in the endocrine cells, which were restricted mainly to the oxyntic mucosa.On the other hand, GRP immunoreactivity in the rat and swine gut was contained in the nerve fibers distributed in the gastric mucosa and in the submucosal and myenteric plexuses of the gut wall.In the lungs of human fetuses, the endocrine cells, solitary or gathered in groups, were immunoreactive to the GRP antisera.These endocrine cells and nerve fibers in the gut and lung showed the same immunoreactivity to two GRP antisera, but not to a bombesin-specific antiserum.This suggests that the bombesinlike immunoreactivities reported in the previous studies may be due to the existence of GRP or GRP-related peptides.Electron microscopic immunocytochemistry revealed that the GRP-like immunoreactivity was localized in the cytoplasmic granules of the pulmonary endocrine cells and in the dense-cored vesicles of the gut nerve fibers.'