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Isobenzofuranones from the aerial parts of Leontopodium leontopodioides (Wild.) Beauv.

2017; Elsevier BV; Volume: 124; Linguagem: Inglês

10.1016/j.fitote.2017.10.019

1873-6971

Yi Zhang, Yuling Yang, Jingya Ruan, Qiu Chen, Jian Li, Yuanqiang Guo, Lifeng Han, Tao Wang,

Natural product bioactivities and synthesis

A phytochemical investigation to obtain new triglyceride (TG) accumulation inhibitors resulted in the isolation of six new isobenzofuranones, leontopodiols A (1), B (2), leontopodiosides C (3), D (4), E (5), F (6), together with three known ones (7-9) from the aerial parts of Leontopodium leontopodioides (Willd.) Beauv. The structures of these isolates were identified by routine NMR experiments, optical rotation determination, electronic circular dichroism (ECD) calculation, along with chemical reaction. Moreover, compounds 1, 2, 5, and 7-9 displayed TG accumulation inhibitory effects on HepG2 cells.