Produção Nacional
Revisado por pares
Multifunctions of Pleurotus sajor-caju (Fr.) Singer: A highly nutritious food and a source for bioactive compounds
2017; Elsevier BV; Volume: 245; Linguagem: Inglês
10.1016/j.foodchem.2017.10.088
ISSN1873-7072
AutoresTiane C. Finimundy, Lillian Barros, Ricardo C. Calhelha, Maria José Alves, Miguel A. Prieto, Rui M.V. Abreu, Aldo José Pinheiro Dillon, João Antônio Pêgas Henriques, Mariana Roesch‐Ely, Isabel C.F.R. Ferreira,
Tópico(s)Phytochemical compounds biological activities
ResumoA study with Pleurotus sajor-caju was conducted to: evaluate the nutritional and chemical composition of the fruiting bodies; optimize the preparation of bioactive phenolic extracts; and characterize the optimized extract in terms of bioactive compounds and properties. P. sajor-caju revealed an equilibrated nutritional composition with the presence of hydrophilic (sugars and organic acids) and lipophilic (tocopherols and PUFA) compounds. p-Hydroxybenzoic, p-coumaric and cinnamic acids were identified in the extract obtained with ethanol (30 g/l ratio) at 55 °C for 85 min. This extract showed antioxidant properties (mainly reducing power and lipid peroxidation inhibition), antibacterial activity against MRSA and MSSA and cytotoxicity against NCI-H460, MCF-7 and HeLa. Furthermore, as the extract showed capacity to inhibit NO production in Raw 264.7 macrophages, molecular docking studies were performed to provide insights into the anti-inflammatory mechanism of action, through COX-2 inhibition by the phenolic acids identified.
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