Portal de Periódicos da CAPES

Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10–p63 axis in epithelial homeostasis

2017; National Academy of Sciences; Volume: 114; Issue: 46 Linguagem: Inglês

10.1073/pnas.1710726114

1091-6490

Bum-Ho Bin, Jinhyuk Bhin, Mikiro Takaishi, Koh‐éi Toyoshima, Saeko Kawamata, Kana Ito, Takafumi Hara, Takashi Watanabe, Tarou Irié, Teruhisa Takagishi, Su-Hyon Lee, Haeng-Sun Jung, Sangchul Rho, Juyeon Seo, Dong‐Hwa Choi, Daehee Hwang, Haruhiko Koseki, Osamu Ohara, Shigetoshi Sano, Takashi Tsuji, Kenji Mishima, Toshiyuki Fukada,

Skin and Cellular Biology Research

Significance Although the epidermis of the skin is the first tissue to manifest a zinc deficiency, the mechanisms underlying zinc-mediated epidermal formation are largely unknown. We demonstrated that the zinc transporter ZIP10, which is highly expressed in the outer root shelf of hair follicles, is essential for epidermal formation. Ablating Zip10 caused epidermal hypoplasia by down-regulating the transcriptional activity of p63, whereas ZIP10-mediated zinc influx promoted p63 transactivation to induce epidermal morphogenesis. Our results establish the physiological relevance of ZIP10 in epidermal development.