Effect of PTX3 and Voriconazole Combination in a Rat Model of Invasive Pulmonary Aspergillosis
2012; American Society for Microbiology; Volume: 56; Issue: 12 Linguagem: Inglês
10.1128/aac.01000-12
ISSN1098-6596
AutoresPietro Giudice, Silvia Campo, Rita De Santis, Giovanni Salvatori,
Tópico(s)Endodontics and Root Canal Treatments
ResumoThis study evaluated the pharmacological activity of PTX3, administered in combination with voriconazole, in a rat model of pulmonary aspergillosis. The data indicated additive therapeutic activities of these compounds, as demonstrated by the amelioration of respiratory function changes, reduction of lung fungal burden, and increased survival. Overall, we provide clear evidence that the combination of PTX3 with a suboptimal dose of voriconazole might represent a therapeutic option under those clinical conditions where the use of voriconazole alone is not warranted for efficacy and tolerability reasons.
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