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Naphthalimide-Based Turn-On Fluorosensor for Aqueous Sulfide Ions for Staining in Living Cells

2017; Wiley; Volume: 2; Issue: 31 Linguagem: Inglês

10.1002/slct.201701351

2365-6549

Somenath Lohar, Abhishek Maji, Siddhartha Pal, Subhra Kanti Mukhopadhyay, Dipta Nag, Nicola Demitri, Pabitra Chattopadhyay,

Luminescence and Fluorescent Materials

ChemistrySelectVolume 2, Issue 31 p. 9977-9983 Full Paper Naphthalimide-Based Turn-On Fluorosensor for Aqueous Sulfide Ions for Staining in Living Cells Somenath Lohar, Somenath Lohar Department of Chemistry, The University of Burdwan, Golapbag, Burdwan, 713104 IndiaSearch for more papers by this authorAbhishek Maji, Abhishek Maji Department of Chemistry, The University of Burdwan, Golapbag, Burdwan, 713104 IndiaSearch for more papers by this authorDr. Siddhartha Pal, Dr. Siddhartha Pal Department of Chemistry, The University of Burdwan, Golapbag, Burdwan, 713104 IndiaSearch for more papers by this authorProf. Subhra Kanti Mukhopadhyay, Prof. Subhra Kanti Mukhopadhyay Department of Microbiology, The University of Burdwan, Golapbag, Burdwan, 713104 IndiaSearch for more papers by this authorDipta Nag, Dipta Nag Department of Microbiology, The University of Burdwan, Golapbag, Burdwan, 713104 IndiaSearch for more papers by this authorDr. Nicola Demitri, Dr. Nicola Demitri Elettra-Sincrotrone Trieste, S.S. 14 Km 163.5 in Area Science Park, 34149 Basovizza Trieste, ItalySearch for more papers by this authorProf. Pabitra Chattopadhyay, Corresponding Author Prof. Pabitra Chattopadhyay pabitracc@yahoo.com Department of Chemistry, The University of Burdwan, Golapbag, Burdwan, 713104 IndiaSearch for more papers by this author Somenath Lohar, Somenath Lohar Department of Chemistry, The University of Burdwan, Golapbag, Burdwan, 713104 IndiaSearch for more papers by this authorAbhishek Maji, Abhishek Maji Department of Chemistry, The University of Burdwan, Golapbag, Burdwan, 713104 IndiaSearch for more papers by this authorDr. Siddhartha Pal, Dr. Siddhartha Pal Department of Chemistry, The University of Burdwan, Golapbag, Burdwan, 713104 IndiaSearch for more papers by this authorProf. Subhra Kanti Mukhopadhyay, Prof. Subhra Kanti Mukhopadhyay Department of Microbiology, The University of Burdwan, Golapbag, Burdwan, 713104 IndiaSearch for more papers by this authorDipta Nag, Dipta Nag Department of Microbiology, The University of Burdwan, Golapbag, Burdwan, 713104 IndiaSearch for more papers by this authorDr. Nicola Demitri, Dr. Nicola Demitri Elettra-Sincrotrone Trieste, S.S. 14 Km 163.5 in Area Science Park, 34149 Basovizza Trieste, ItalySearch for more papers by this authorProf. Pabitra Chattopadhyay, Corresponding Author Prof. Pabitra Chattopadhyay pabitracc@yahoo.com Department of Chemistry, The University of Burdwan, Golapbag, Burdwan, 713104 IndiaSearch for more papers by this author First published: 02 November 2017 https://doi.org/10.1002/slct.201701351Citations: 6Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract A new naphthalimide based selective chemosensor detects aqueous sulfide ion as low as 2.4 μM in at biological pH through single point fluorescence enhancement based on ICT mechanism which has been established considering all the spectroscopic data obtained from a series of four similar type newly synthesized naphthalimide based organic moieties. The non-cytotoxic probe is also useful in acquiring the fluorescent image of the distribution of sulfide ions in living cells. Abstract A newly synthesized and characterized naphthalimide derivative (L1) acts as a highly sensitive chemosensor for aqueous sulfide ions in water/DMSO (3:1, v/v) medium as L1 offers distinctive reactive properties toward aqueous sulfide ions to be converted to L1A of potential turn-on fluorescent properties over other competitive anions. Gradual addition of aqueous sulfide ions led to the formation of in situ L1A compound which showed a single point fluorescence enhancement based on intramolecular charge transfer (ICT). To establish this new interesting pathway in favor of ICT for sensing sulfide ions, the detailed spectroscopic studies of other three similar type new 1,8-naphthalimide based organic probes (L2, L3 and L4) duly structurally characterized including theoretical (DFT) studies have been carried out systematically. The probe (L1) detects aqueous sulfide ions as low as 2.4 μM in at biological pH within a very short responsive time (15-20 s) and this non-cytotoxic the probe, L1 is also useful in acquiring the fluorescent image of the distribution of sulfide ions in living cells using fluorescence microscope. Conflict of interest The authors declare no conflict of interest. Citing Literature Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description slct201701351-sup-0001-misc_information.pdf2.4 MB Supplementary Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume2, Issue31October 31, 2017Pages 9977-9983 RelatedInformation