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Lateral hypothalamic activity indicates hunger and satiety states in humans

2017; Wiley; Volume: 4; Issue: 12 Linguagem: Inglês

10.1002/acn3.466

2328-9503

Omid Talakoub, Raquel R. Paiva, Matija Milosevic, Marcelo Q. Hoexter, Ruth Rocha Franco, Eduardo Joaquim Lopes Alho, Jessie Navarro, José F. Pereira, Miloš R. Popović, Cary R. Savage, Antônio Carlos Lopes, Pedro Gomes de Alvarenga, Durval Damiani, Manoel J. Teixeira, Eurípedes C. Miguel, Erich Talamoni Fonoff, Marcelo C. Batistuzzo, Clement Hamani,

Neuroscience of respiration and sleep

Abstract Lateral hypothalamic area ( LHA ) local field potentials ( LFP s) were recorded in a Prader–Willi patient undergoing deep brain stimulation ( DBS ) for obesity. During hunger, exposure to food‐related cues induced an increase in beta/low‐gamma activity. In contrast, recordings during satiety were marked by prominent alpha rhythms. Based on these findings, we have delivered alpha‐frequency DBS prior to and during food intake. Despite reporting an early sensation of fullness, the patient continued to crave food. This suggests that the pattern of activity in LHA may indicate hunger/satiety states in humans but attest to the complexity of conducting neuromodulation studies in obesity.