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Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

2017; American Association for the Advancement of Science; Volume: 359; Issue: 6371 Linguagem: Inglês

10.1126/science.aan4236

1095-9203

Vancheswaran Gopalakrishnan, Christine N. Spencer, Luigi Nezi, Alexandre Reuben, Miles C. Andrews, Tatiana V. Karpinets, Peter A. Prieto, Diego Vicente, Kristi L. Hoffman, Spencer C. Wei, Alexandria P. Cogdill, Li Zhao, Courtney W. Hudgens, Diane S. Hutchinson, Teresa Manzo, Mariana Petaccia de Macêdo, Tiziana Cotechini, Tapsi Kumar, W. S. Chen, Sangeetha M. Reddy, Robert Szczepaniak‐Sloane, Jessica Galloway-Peña, Hong Jiang, P. L. Chen, Elizabeth J. Shpall, Katayoun Rezvani, Amin M. Alousi, Roy F. Chemaly, Samuel A. Shelburne, Luis M. Vence, Pablo C. Okhuysen, V. Behrana Jensen, Alton G. Swennes, Florencia McAllister, Erick Riquelme, Yexi Zhang, Emmanuelle Le Chatelier, Laurence Zitvogel, Nicolas Pons, Jacob L. Austin-Breneman, Lauren E. Haydu, Elizabeth M. Burton, Julie M. Gardner, Elizabeth Sirmans, Jiemiao Hu, Alexander J. Lazar, Takahiro Tsujikawa, Adi Diab, Hussein A. Tawbi, Isabella C. Glitza, Wen-Jen Hwu, Sapna P. Patel, Scott E. Woodman, Rodabe N. Amaria, Michael A. Davies, Jeffrey E. Gershenwald, Patrick Hwu, Juneyoung Lee, J. Zhang, Lisa M. Coussens, Zachary A. Cooper, P. Andrew Futreal, Carrie R. Daniel, Nadim J. Ajami, Joseph F. Petrosino, Michael T. Tetzlaff, Padmanee Sharma, James P. Allison, Robert R. Jenq, Jennifer A. Wargo,

Dermatology and Skin Diseases

Good bacteria help fight cancer Resident gut bacteria can affect patient responses to cancer immunotherapy (see the Perspective by Jobin). Routy et al. show that antibiotic consumption is associated with poor response to immunotherapeutic PD-1 blockade. They profiled samples from patients with lung and kidney cancers and found that nonresponding patients had low levels of the bacterium Akkermansia muciniphila . Oral supplementation of the bacteria to antibiotic-treated mice restored the response to immunotherapy. Matson et al. and Gopalakrishnan et al. studied melanoma patients receiving PD-1 blockade and found a greater abundance of “good” bacteria in the guts of responding patients. Nonresponders had an imbalance in gut flora composition, which correlated with impaired immune cell activity. Thus, maintaining healthy gut flora could help patients combat cancer. Science , this issue p. 91 , p. 104 , p. 97 ; see also p. 32