Artigo Acesso aberto Revisado por pares

Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

2017; Nature Portfolio; Volume: 7; Issue: 1 Linguagem: Inglês

10.1038/s41598-017-11852-3

ISSN

2045-2322

Autores

Liz Rietschel, Fabian Streit, Gu Zhu, Kerrie McAloney, Josef Frank, Baptiste Couvy‐Duchesne, Stephanie H. Witt, Tina M. Binz, Jennifer L. Bolton, Caroline Hayward, Neşe Direk, Anna Anderson, Jennifer E. Huffman, James F. Wilson, Harry Campbell, Igor Rudan, Alan F. Wright, Nicholas D. Hastie, Sarah H. Wild, Fleur P. Velders, Albert Hofman, André G. Uitterlinden, Jari Lahti, Katri Räikkönen, Eero Kajantie, Elisabeth Widén, Aarno Palotie, Johan G. Eriksson, Marika Kaakinen, Marjo‐Riitta Järvelin, Nicholas J. Timpson, George Davey Smith, Susan M. Ring, David M. Evans, Beaté St Pourcain, Toshiko Tanaka, Yuri Milaneschi, Stefania Bandinelli, Luigi Ferrucci, Pim van der Harst, Judith G.M. Rosmalen, Stephen J. L. Bakker, Niek Verweij, Robin P. F. Dullaart, Anubha Mahajan, Cecilia M. Lindgren, Andrew P. Morris, Lars Lind, Erik Ingelsson, Laura N. Anderson, Craig E. Pennell, Stephen J. Lye, Stephen G. Matthews, Joel Eriksson, Dan Mellström, Claes Ohlsson, Jackie F. Price, Mark W. J. Strachan, Rebecca M. Reynolds, Henning Tiemeier, Stephan Ripke, Manuel Mattheisen, Abdel Abdellaoui, Mark J. Adams, Esben Agerbo, Tracy Air, Till F. M. Andlauer, Silviu‐Alin Bacanu, Marie Bækvad‐Hansen, Aartjan T.F. Beekman, David A. Bennett, Kenneth I. Berger, Tim B. Bigdeli, Jonas Bybjerg‐Grauholm, Enda M. Byrne, Na Cai, Enrique Castelao, Toni‐Kim Clarke, Jonathan R. I. Coleman, CPTAC Clinical Proteomic Tumor Analysis Consortium, Nick Craddock, Udo Dannlowski, Gareth E. Davies, Gail Davies, Eco J. C. de Geus, Philip L. De Jager, Ian J. Deary, Franziska Degenhardt, Erin C. Dunn, Erik A. Ehli, Thalia C. Eley, Valentina Escott‐Price, Tõnu Esko, Hilary K. Finucane, Michael Gill, Scott D. Gordon, Jakob Grove, Lynsey S. Hall, Thomas Hansen, Christine Søholm Hansen, Thomas Hansen, Andrew C. Heath, Anjali K. Henders, Stefan Herms, Per Hoffmann, Georg Homuth, Carsten Horn, Jouke‐Jan Hottenga, David M. Hougaard, Hailiang Huang, Marcus Ising, Rick Jansen, Eric Jorgenson, Stefan Kloiber, James A. Knowles, Warren W. Kretzschmar, Jesper Krogh, Zoltán Kutalik, Maren Lang, Glyn Lewis, Yihan Li, Donald J. MacIntyre, P.A. Madden, Jonathan Marchine, Hamdi Mbarek, Peter McGuffin, Divya Mehta, Andres Metspalu, Christel M. Middeldorp, Evelin Mihailov, Lili Milani, Grant W. Montgomery, Sara Mostafavi, Niamh Mullins, Matthias Nauck, Bernard Ng, Merete Nordentoft, Dale R. Nyholt, Michael O’Donovan, Paul F. O’Reilly, Högni Óskarsson, Michael J. Owen, Sara A. Paciga, Carsten Bøcker Pedersen, Marianne Giørtz Pedersen, Nancy L. Pedersen, Michele L. Pergadia, Roseann E. Peterson, Erik Pettersson, Wouter J. Peyrot, David J. Porteous, Daniëlle Posthuma, James B. Potash, Jorge A. Quiroz, John P. Rice, Brien P. Riley, Margarita Rivera, Douglas M. Ruderfer, Saira Saeed Mirza, Robert A. Schoevers, Ling Shen, Jianxin Shi, Engilbert Sigurðsson, Grant CB Sinnamon, Johannes H. Smit, Daniel J. Smıth, Jordan W. Smoller, Hreinn Stephansson, Stacy Steinberg, Jana Strohmaier, Katherine E. Tansey, Alexander Teumer, Wesley K. Thompson, Pippa A. Thomson, Thorgeir E. Thorgeirsson, Jens Treutlein, Maciej Trzaskowski, Daniel Umbricht, Sandra Van der Auwera, Gerard van Grootheest, Albert M. van Hemert, Alexander Viktorin, Henry Völzke, Yunpeng Wang, Bradley T. Webb, Myrna M. Weissman, Jürgen Wellmann, Gonneke Willemsen, Hualin Simon Xi, Bernhard T. Baune, Douglas Blackwood, Dorret I. Boomsma, Anders D. Børglum, Henriette N. Buttenschøn, Sven Cichon, Enrico Domenici, Jonathan Flint, Hans J. Grabe, Steven P. Hamilton, Kenneth S. Kendler, Qingqin S. Li, Susanne Lucae, Patrik K. E. Magnusson, Andrew M. McIntosh, Ole Mors, Preben Bo Mortensen, Bertram Müller‐Myhsok, Brenda W.J.H. Penninx, Roy H. Perlis, Martin Preisig, Catherine Schaefer, Jordan W. Smoller, Kari Stephansson, Henning Tiemeier, Rudolf Uher, Thomas Werge, Ashley R. Winslow, Gerome Breen, Douglas F. Levinson, Cathryn M. Lewis, Naomi R. Wray, Patrick F. Sullivan, John J. McGrath, Ian B. Hickie, Narelle K. Hansell, Margaret J. Wright, Nathan A. Gillespie, Andreas J. Forstner, Thomas G. Schulze, Stefan Wüst, Markus M. Nöthen, Markus R. Baumgartner, Brian R. Walker, Andrew Crawford, Lucía Colodro‐Conde, Sarah E. Medland, Nicholas G. Martin, Marcella Rietschel,

Tópico(s)

Hypothalamic control of reproductive hormones

Resumo

Abstract Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains unclear. The aims of the present twin study were to: (i) assess the heritability of HCC; (ii) estimate the phenotypic and genetic correlation between HPA axis activity and the psychological variables perceived stress, depressive symptoms, and neuroticism; using formal genetic twin models and molecular genetic methods, i.e. polygenic risk scores (PRS). HCC was measured in 671 adolescents and young adults. These included 115 monozygotic and 183 dizygotic twin-pairs. For 432 subjects PRS scores for plasma cortisol, major depression, and neuroticism were calculated using data from large genome wide association studies. The twin model revealed a heritability for HCC of 72%. No significant phenotypic or genetic correlation was found between HCC and the three psychological variables of interest. PRS did not explain variance in HCC. The present data suggest that HCC is highly heritable. However, the data do not support a strong biological link between HCC and any of the investigated psychological variables.

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