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BIBTEX RIS

Absolute configurations of griseorhodins A and C

2017; Elsevier BV; Volume: 58; Issue: 50 Linguagem: Inglês

10.1016/j.tetlet.2017.11.008

ISSN

1873-3581

Autores

Humberto E. Ortega, João M. Batista, Weilan Gomes da Paixão Melo, Jon Clardy, Mônica Tallarico Pupo,

Tópico(s)

Chemical synthesis and alkaloids

Resumo

The known antibiotic and cytotoxic compounds griseorhodin A (1) and griseorhodin C (2) were produced in solid culture by Streptomyces puniceus AB10, which was isolated from the leaf-cutter ant Acromyrmex rugosus rugosus. Their absolute configurations were unambiguously established as 6S,6aR,7S,8S and 6R,6aR,7S,8R, respectively, using vibrational circular dichroism (VCD) and density functional theory (DFT) calculations.

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