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BIBTEX RIS

Anticancer and Immunogenic Properties of Cardiac Glycosides

2017; Multidisciplinary Digital Publishing Institute; Volume: 22; Issue: 11 Linguagem: Inglês

10.3390/molecules22111932

ISSN

1433-1373

Autores

Naira Fernanda Zanchett Schneider, Claudia Cerella, Cláudia Maria Oliveira Simões, Marc Diederich,

Tópico(s)

Biochemical and Molecular Research

Resumo

Cardiac glycosides (CGs) are natural compounds widely used in the treatment of several cardiac conditions and more recently have been recognized as potential antitumor compounds. They are known to be ligands for Na/K-ATPase, which is a promising drug target in cancer. More recently, in addition to their antitumor effects, it has been suggested that CGs activate tumor-specific immune responses. This review summarizes the anticancer aspects of CGs as new strategies for immunotherapy and drug repositioning (new horizons for old players), and the possible new targets for CGs in cancer cells.

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