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Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations

2017; Wiley; Volume: 142; Issue: 6 Linguagem: Inglês

10.1002/ijc.31146

1097-0215

Fränzel J.B. van Duijnhoven, Mazda Jenab, Kristian Hveem, Peter D. Siersema, Veronika Fedirko, Eric J. Duell, Ellen Kampman, Anouk Halfweeg, Henk J. van Kranen, Jody M.W. van den Ouweland, Elisabete Weiderpass, Neil Murphy, Arnulf Langhammer, Eivind Ness‐Jensen, Anja Olsen, Anne Tjønneland, Kim Overvad, Claire Cadeau, Marina Kvaskoff, Marie‐Christine Boutron‐Ruault, Verena Katzke, Tilman Kühn, Heiner Boeing, Antonia Trichopoulou, Αναστασία Κοτανίδου, Maria Kritikou, Domenico Palli, Claudia Agnoli, ­Rosario ­Tumino, Salvatore Panico, Giuseppe Matullo, Petra H. Peeters, Magritt Brustad, Karina Standahl Olsen, Cristina Lasheras, Mireia Obón‐Santacana, María‐José Sánchez, Miren Dorronsoro, María‐Dolores Chirlaque, Aurelio Barricarte, Jonas Manjer, Martin Almquist, Frida Renström, Weimin Ye, Nicholas J. Wareham, Kay‐Tee Khaw, Kathryn E. Bradbury, Heinz Freisling, Dagfinn Aune, Teresa Norat, Elio Ríboli, H. Bas Bueno‐de‐Mesquita,

Electrolyte and hormonal disorders

Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D