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Chemical Biology of H 2 S Signaling through Persulfidation

2017; American Chemical Society; Volume: 118; Issue: 3 Linguagem: Inglês

10.1021/acs.chemrev.7b00205

1520-6890

Miloš R. Filipović, Jasmina Živanović, Beatriz Álvarez, Ruma Banerjee,

Alcohol Consumption and Health Effects

Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for understanding the physiological and pharmacological effects of H2S. Due to the inherent instability of persulfides, their chemistry is understudied. In this review, we discuss the biologically relevant chemistry of H2S and the enzymatic routes for its production and oxidation. We cover the chemical biology of persulfides and the chemical probes for detecting them. We conclude by discussing the roles ascribed to protein persulfidation in cell signaling pathways.