The corepressor NCOR1 regulates the survival of single-positive thymocytes
2017; Nature Portfolio; Volume: 7; Issue: 1 Linguagem: Inglês
10.1038/s41598-017-15918-0
ISSN2045-2322
AutoresLena Müller, Daniela Hainberger, Valentina Stolz, Patricia Hamminger, Hammad Hassan, Teresa Preglej, Nicole Boucheron, Shinya Sakaguchi, G. Jan Wiegers, Andreas Villunger, Johan Auwerx, Wilfried Ellmeier,
Tópico(s)Toxin Mechanisms and Immunotoxins
ResumoNuclear receptor corepressor 1 (NCOR1) is a transcriptional regulator bridging repressive chromatin modifying enzymes with transcription factors. NCOR1 regulates many biological processes, however its role in T cells is not known. Here we show that Cd4-Cre-mediated deletion of NCOR1 (NCOR1 cKO
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