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Ivy and Licorice Triterpene Glycosides: Promising Molecular Containers for Some Drugs and Biomolecules

2017; Elsevier BV; Linguagem: Inglês

10.1016/b978-0-444-64068-0.00011-5

2542-6621

L. A. Yakovishin, V. I. Grishkovets,

Toxin Mechanisms and Immunotoxins

The molecular complexation of triterpene glycosides with different drugs and biologically active molecules is widely studied. The great interest to these supramolecular products is caused by the possibility to reduce of drug doses, bioavailability and decomposition resistance increasement, the action prolongation, and expansion of pharmacological activity spectrum of drugs and triterpene glycosides. Mainly investigated molecular encapsulation for glycyrrhizic acid (3-О-β-d-glucopyranosyl-(1 → 2)-О-β-d-glucopyranoside of glycyrrhetinic acid) and its monoammonium salt (monoammonium glycyrrhizinate, glycyram). Glycyrrhizic acid is the main triterpene glycoside of the licorice Glycyrrhiza glabra L. (Fabaceae). Triterpene glycosides α-hederin (3-О-α-l-rhamnopyranosyl-(1 → 2)-О-α-l-arabinopyranoside of hederagenin) and hederasaponin C (3-О-α-l-rhamnopyranosyl-(1 → 2)-О-α-l-arabinopyranosyl-28-О-α-l-rhamnopyranosyl-(1 → 4)-О-β-d-glucopyranosyl-(1 → 6)-О-β-d-glucopyranoside of hederagenin) are prospective molecular containers of biologically active substances and medicines. Glycosides α-hederin and hederasaponin C were discovered in representatives of most species of the ivy genus Hedera L. (Araliaceae). This review considers the molecular complexes of ivy and licorice glycosides with tetracyclines and anthracyclines, derivatives of pyrazolopyrimidine, salicylic and phenylpropionic acids, aniline, indole, pyrazolone and pyrazolidone, aromatic nitro compounds, sulfonamides, amino acids, nitrogenous bases of nucleic acids, and alkaloids. The biological activity of molecular complexes of ivy and licorice triterpene glycosides has been showed.