Pathology of Experimental Vitamin D Deficiency in Chickens and Effects of Treatment with Vitamin D Metabolites
1981; SAGE Publishing; Volume: 18; Issue: 5 Linguagem: Inglês
10.1177/030098588101800509
ISSN1544-2217
Autores Tópico(s)Vitamin D Research Studies
ResumoStructural changes in bone, parathyroid, and ultimobranchial body were examined in three groups of chicks fed a vitamin D-deficient diet; one group was treated with vitamin D 3 and another with 1,25(OH) 2 D 3 . Diets were fed from day of hatching until 5 weeks old, when deficient chicks were near death due to hypocalcemic tetany, loss of fat and muscle, and marked bone deformities. In deficient chicks, parathyroid mass increased linearly to 7.5 times normal at 5 weeks. Parathyroid cells were irregular and vacuolated, with few granules. Vitamin D 3 treatment (daily from hatching) prevented these changes. Chicks treated with 1,25(OH) 2 D 3 had normal parathyroids until the fifth week, when parathyroid mass increased greatly. There were few differences in length of growth cartilage, but marked changes in length of metaphyses. Deficient chicks had metaphyses nearly five times longer than vitamin D 3 -treated chicks. Metaphyses in chicks given 1,25(OH) 2 D 3 were twice as long as those of vitamin D-treated chicks at 5 weeks. Both osteoblasts and osteoclasts were more numerous in deficient chicks. These studies suggest that vitamin D 3 is more effective than 1,25(OH) 2 D 3 in preventing parathyroid and bone lesions of vitamin D deficiency.
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