Voltar
Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Neurofilament light chain predicts disease activity in relapsing-remitting MS

2017; Wolters Kluwer; Volume: 5; Issue: 1 Linguagem: Inglês

10.1212/nxi.0000000000000422

ISSN

2332-7812

Autores

Kristin N. Varhaug, Christian Barro, Kjetil Bjørnevik, Kjell‐Morten Myhr, Øivind Torkildsen, Stig Wergeland, Laurence A. Bindoff, Jens Kühle, Christian A. Vedeler,

Tópico(s)

Viral Infections and Immunology Research

Resumo

To investigate whether serum neurofilament light chain (NF-L) and chitinase 3-like 1 (CHI3L1) predict disease activity in relapsing-remitting MS (RRMS).A cohort of 85 patients with RRMS were followed for 2 years (6 months without disease-modifying treatment and 18 months with interferon-beta 1a [IFNB-1a]). Expanded Disability Status Scale was scored at baseline and every 6 months thereafter. MRI was performed at baseline and monthly for 9 months and then at months 12 and 24. Serum samples were collected at baseline and months 3, 6, 12, and 24. We analyzed the serum levels of NF-L using a single-molecule array assay and CHI3L1 by ELISA and estimated the association with clinical and MRI disease activity using mixed-effects models.NF-L levels were significantly higher in patients with new T1 gadolinium-enhancing lesions (37.3 pg/mL, interquartile range [IQR] 25.9-52.4) and new T2 lesions (37.3 pg/mL, IQR 25.1-48.5) compared with those without (28.0 pg/mL, IQR 21.9-36.4, β = 1.258, p < 0.001 and 27.7 pg/mL, IQR 21.8-35.1, β = 1.251, p < 0.001, respectively). NF-L levels were associated with the presence of T1 gadolinium-enhanced lesions up to 2 months before (p < 0.001) and 1 month after (p = 0.009) the time of biomarker measurement. NF-L levels fell after initiation of IFNB-1a treatment (p < 0.001). Changes in CHI3L1 were not associated with clinical or MRI disease activity or interferon-beta 1a treatment.Serum NF-L could be a promising biomarker for subclinical MRI activity and treatment response in RRMS. In clinically stable patients, serum NF-L may offer an alternative to MRI monitoring for subclinical disease activity.NCT00360906.

Referência(s)