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UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis

2017; Nature Portfolio; Volume: 23; Issue: 12 Linguagem: Inglês

10.1038/nm.4429

1546-170X

Kenji Ikeda, Qianqian Kang, Takeshi Yoneshiro, João Paulo Camporez, Hiroko Maki, Mayu Homma, Kosaku Shinoda, Yong Chen, Xiaodan Lü, Pema Maretich, Kazuki Tajima, Kolapo M. Ajuwon, Tomoyoshi Soga, Shingo Kajimura,

Muscle metabolism and nutrition

Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat remains unclear. Here we report a robust UCP1-independent thermogenic mechanism in beige fat that involves enhanced ATP-dependent Ca