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Separation of glycosidic catiomers by TWIM‐MS using CO 2 as a drift gas

2015; Wiley; Volume: 50; Issue: 2 Linguagem: Inglês

10.1002/jms.3532

1096-9888

Giovana A. Bataglion, Gustavo H.M.F. Souza, Gabriel Heerdt, Nelson H. Morgon, José Diogo L. Dutra, Ricardo O. Freire, Marcos N. Eberlin, Alessandra Tata,

Advanced Chemical Sensor Technologies

Traveling wave ion mobility mass spectrometry (TWIM‐MS) is shown to be able to separate and characterize several isomeric forms of diterpene glycosides stevioside (Stv) and rebaudioside A (RebA) that are cationized by Na + and K + at different sites. Determination and characterization of these coexisting isomeric species, herein termed catiomers, arising from cationization at different and highly competitive coordinating sites, is particularly challenging for glycosides. To achieve this goal, the advantage of using CO 2 as a more massive and polarizable drift gas, over N 2 , was demonstrated. Post‐TWIM‐MS/MS experiments were used to confirm the separation. Optimization of the possible geometries and cross‐sectional calculations for mobility peak assignments were also performed. Copyright © 2015 John Wiley & Sons, Ltd.