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Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia

2017; American Medical Association; Volume: 75; Issue: 1 Linguagem: Inglês

10.1001/jamapsychiatry.2017.3391

2168-6238

Willemijn J. Jansen, Rik Ossenkoppele, Betty M. Tijms, Anne M. Fagan, Oskar Hansson, William E. Klunk, Wiesje M. van der Flier, Victor L. Villemagne, Giovanni B. Frisoni, Adam Fleisher, Alberto Lleó, Mark A. Mintun, Anders Wallin, Sebastiaan Engelborghs, Duk L. Na, Gaël Chételat, José Luís Molinuevo, Susan Landau, Niklas Mattsson, Johannes Kornhuber, Osama Sabri, Christopher C. Rowe, Lucilla Parnetti, Julius Popp, Tormod Fladby, William J. Jagust, Pauline Aalten, Dong Young Lee, Rik Vandenberghe, Catarina R. Oliveira, Elisabeth Kapaki, Lutz Froelich, Adrian Ivanoiu, Tomasz Gabryelewicz, Marcel M. Verbeek, Pascual Sánchez‐Juan, Helmut Hildebrandt, Vincent Camus, Marzena Zboch, David J. Brooks, Alexander Drzezga, Juha O. Rinne, Andrew B. Newberg, Alexandre de Mendonça, Marie Sarazin, Gil D. Rabinovici, Karine Madsen, Milica G. Kramberger, Agneta Nordberg, Vincent Mok, Barbara Mroczko, David A. Wolk, Philipp T. Meyer, Magda Tsolaki, Philip Scheltens, Frans R.J. Verhey, Pieter Jelle Visser, Dag Aarsland, Daniel Alcolea, M Alexander, Ina S. Almdahl, Steven E. Arnold, Inês Baldeiras, Henryk Barthel, Bart N.M. van Berckel, Kaj Blennow, Mark A. van Buchem, Enrica Cavedo, Kewei Chen, Elena Chipi, Ann D. Cohen, Stefan Förster, Juan Fortea, Kristian Steen Frederiksen, Yvonne Freund‐Levi, Olymbia Gkatzima, Mark Forrest Gordon, Timo Grimmer, Harald Hampel, Lucrezia Hausner, Sabine Hellwig, Sanna‐Kaisa Herukka, Peter Johannsen, Aleksandra Klimkowicz‐Mrowiec, Sebastian Köhler, Norman Koglin, Koen Van Laere, Mony J. de Leon, Viviana Lisetti, Wolfgang Maier, Jan Marcusson, Olga Meulenbroek, Hanne M. Møllergård, John C. Morris, Arto Nordlund, Gerald Novak, George P. Paraskevas, Gayan Perera, Oliver Peters, Inez H.G.B. Ramakers, Lorena Rami, Eloy Rodríguez‐Rodríguez, Catherine M. Roe, Uroš Rot, Eckart Rüther, Isabel Santana, Johannes Schröder, Sang Won Seo, Hilkka Soininen, Luiza Spiru, Erik Stomrud, Hanne Struyfs, Charlotte E. Teunissen, Stephanie J. B. Vos, Linda Josephine Christine van Waalwijk van Doorn, Gunhild Waldemar, Åsa K. Wallin, Jens Wiltfang, Henrik Zetterberg,

Neurological Disease Mechanisms and Treatments

Cerebral amyloid-β aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and cognitive manifestation in persons without dementia is important for a better understanding of the course of AD and for the design of prevention trials.To investigate whether amyloid-β aggregation is associated with cognitive functioning in persons without dementia.This cross-sectional study included 2908 participants with normal cognition and 4133 with mild cognitive impairment (MCI) from 53 studies in the multicenter Amyloid Biomarker Study. Normal cognition was defined as having no cognitive concerns for which medical help was sought and scores within the normal range on cognitive tests. Mild cognitive impairment was diagnosed according to published criteria. Study inclusion began in 2013 and is ongoing. Data analysis was performed in January 2017.Global cognitive performance as assessed by the Mini-Mental State Examination (MMSE) and episodic memory performance as assessed by a verbal word learning test. Amyloid aggregation was measured with positron emission tomography or cerebrospinal fluid biomarkers and dichotomized as negative (normal) or positive (abnormal) according to study-specific cutoffs. Generalized estimating equations were used to examine the association between amyloid aggregation and low cognitive scores (MMSE score ≤27 or memory z score≤-1.28) and to assess whether this association was moderated by age, sex, educational level, or apolipoprotein E genotype.Among 2908 persons with normal cognition (mean [SD] age, 67.4 [12.8] years), amyloid positivity was associated with low memory scores after age 70 years (mean difference in amyloid positive vs negative, 4% [95% CI, 0%-7%] at 72 years and 21% [95% CI, 10%-33%] at 90 years) but was not associated with low MMSE scores (mean difference, 3% [95% CI, -1% to 6%], P = .16). Among 4133 patients with MCI (mean [SD] age, 70.2 [8.5] years), amyloid positivity was associated with low memory (mean difference, 16% [95% CI, 12%-20%], P < .001) and low MMSE (mean difference, 14% [95% CI, 12%-17%], P < .001) scores, and this association decreased with age. Low cognitive scores had limited utility for screening of amyloid positivity in persons with normal cognition and those with MCI. In persons with normal cognition, the age-related increase in low memory score paralleled the age-related increase in amyloid positivity with an intervening period of 10 to 15 years.Although low memory scores are an early marker of amyloid positivity, their value as a screening measure for early AD among persons without dementia is limited.