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BIBTEX RIS

Proceedings of the 2017 WAO Symposium on Hot Topics in Allergy: Pediatric & Regulatory Aspects

2017; Elsevier BV; Volume: 10; Linguagem: Inglês

10.1186/s40413-017-0170-3

1939-4551

Giovanni Traina, Rocco Luigi Valluzzi, Vincenzo Fierro, Carla Riccardi, Maria Cristina Artesani, Andrea De Vuono, Alessandro Fiocchi, Alberto Giuseppe Martelli, Luis A. Ríos, Christian R Alcocer, Elsy Navarrete, Blanca Estela del Río Navarro, Victor Gonzalez, Berenice Velasco, Herberth J Perez Aviles, Roberto Jose Fernandez, Faustino Pozo, Abdal Jabbar Farhan, Syed Hasan Arshad, Ahmed Hussain, Olena Sharikadze, О.M. Okhotnikova, Javier Alcover, Diego Rodríguez, Fernando Pineda, Ilan Dalal, Jenny Weinbrand-Goichberg, Shira Benor, Menachem Rottem, Shmuel Kivity, Sakura Sato, Noriyuki Yanagida, Motohiro Ebisawa, Т.Р. Уманец, Fernando Pineda, Youriy Antipkin, Vladyslava Barzylovich, V.F. Lapshyn, Т.Р. Уманец, Mykola Umanets, Sergey Yuriev, Fernando Pineda, Diego Rodríguez, Javier Alcover, Suzan Bekir, Tobias Pincock, Alberto Vieira Hernandez, Arnaldo Capriles Hulett, Mario Sánchez Borges, Fabiola Fabiano, Carlos Albarran, Rohit Goyal, Shilpa Gupta, Garg Gaurav, Allan T. Luskin, Noelle M. Griffin, A.L. Wagelie-Steffen, Benjamin Trzaskoma, Susan L. Limb, William W. Busse, Robert S. Zeiger, Erika Gonzalez-Reyes, Thomas B. Casale, Bradley E. Chipps, Chizuko Sugizaki, Fumiko Goto, Sakura Sato, Noriyuki Yanagida, Motohiro Ebisawa, Akiko Yamaide, Kanako Mitsunaga, Minako Tomiita, Akira Hoshioka, Naoki Shimojo, Liviu Pop, Ioana-Mihaela Ciucǎ, L. Tămaş, M Lăzărescu, Corina Pienar, Fumiya Yamaide, Bahrul Fikri, Hironori Sato, Naoki Shimojo, Naoko Okishima, M Kobayashi, Mizuki Takai, Kotarou Nishigata, Ryou Yoda, Yu-Ta Oana, Chifu Kajiwara, Moe Shimodaira, Tomoka Suzuki, Hiromi Iizawa, Koji Kamijo, Bijoya Karmakar, Swati Gupta Bhattacharya, Simona Blohlávková, Eliška Kopelentová, Petr Víšek, Jakub Štádler, Ivana Šetinová, Jana Novobílská, Krisa Lundelin, Seppo Salminen, Erika Isolauri, Tracy Pitt, Tamar Flanders, M Rodríguez Peñalver, Patricia Martínez‐Sánchez, M Lluch, A. Malet, Young‐Hee Nam, Hyun Jung Jin, Soo-Keol Lee, Prapasri Kulalert, Paskorn Sritipsukho, Jayanton Pathumanond, Krasimira Baynova, Marina Labella, Teresa De Aramburu, Manuel Prados, Leena Haanpää, Jasmin Aarnio, Merja Nermes, Piia af Ursin, Anne Kaljonen, Erika Isolauri, Nandana Bala, Ketaki Bhagwat, James P. Hindley, Martin D. Chapman, Sivasankar Baalasubramanian, Lilijana Besednjak-Kocijančič, Koyel SenGupta, Swati Gupta Bhattacharya, Bradley E. Chipps, Evgeniya Antonova, Amanda M. Kong, Ahmar Iqbal, W. Gerald Teague, Bradley E. Chipps, Evgeniya Antonova, Benjamin Trzaskoma, Benjamin Ortiz, Brandee Paknis, A. Iqbal, Karin Rosén, Stanley J. Szefler, Afaf Alblooshi, Suleiman Al‐Hammadi, Arantza Vega, Raquel Gutiérrez-Rivas, Ana Alonso, Juan María Beitia, Maria Belén Mateo, Remedios Cárdenas, J.J. Garcı́a, Raquel Pitchon dos Reis, Cristina Gonçalves Alvim, Cláudia Ribeiro de Andrade, Adriana Pitchon dos Reis, Henrique B. Ribeiro, Carmen Bunu, Laura Marusciac, Sorin Paralescu, Paul Tamas, Carmen Panitescu Bunu, Laura Marusciac, Sorin Paralescu, Paul Tamas, E Martí Guadaño, Carolina Escobar Bolaños, Natalia Martí José, Pol Pau Casanovas, Gemma Biarnés Rib, Mariana Castells, Talía de Vicente Jiménez, Maurizio Mennini, Carla Riccardi, Papola De Angelis, Francesca Rea, Monica Malamisura, Renato Tambucci, Alessandro Fiocchi, Luigi Dall’Oglio, Maurizio Mennini, Federica Del Chierico, Tania Napolitano, Silvia Reddel, Pamela Vernocchi, A D’Ambrosio, Lorenza Putignani, Maria Cristina Artesani, Lamia Dahdah, Vincenzo Fierro, Claudia Banzato, Luis Ángel Echeverría Zudaire, Ana María Plaza, Montserrat Bosque García, M. Ibero, Oscar Mazzina, Vincenzo Fierro, Valeria Marzano, Carla Riccardi, Oscar Mazzina, Lamia Dahdah, Maurizio Mennini, Maria Cristina Artesani, Oscar Mazzina, Valeria Pecora, Pierluigi Koch, Rocco Luigi Valluzzi, Vincenzo Fierro, Alessandro Fiocchi, Valentina Pecora, Diletta Valentini, Maurizio Mennini, Lamia Dahdah, Oscar Mazzina, Francesca Santamaria, Rocco Luigi Valluzzi, Anwesha Mukherjee, Amit D. Kandhare, Subhash L. Bodhankar,

Biomedical and Chemical Research

BACKGROUNDIn pediatric ages, sublingual immunotherapy (SLIT) allows allergic children to approach the inhaling desensitizing therapy.However, SLIT causes quite a few compliance problems and sometimes it is difficult to carry it out for the required long term.The alternative is subcutaneous immunotherapy (SCIT), commonly performed with a syringe.This technique hasn't changed much in time and it is not without risks or discomfort.This has led to the search for alternative ways of vaccine administration, in order to reduce discomfort to children by improving compliance and diminishing the potential risks of adverse reactions.OBJECTIVE The study aimed to assess the patient's perceived pain and the safety of a new way of administration of SCIT, with a needleless device.METHODS Children with grass or mite-induced allergic rhinoconjunctivitis and/ or bronchial asthma were prescribed a glutaraldehyde-polymerized allergenic extract (Allergovac Polymeryzed®, Bial Aristegui, Italy).Each dose was divided in two parts: half injected with the traditional syringe (dose A), half in the other arm with a needleless device (Injex, Greytree, Ross on Wye, UK; dose B).Patients were blindfolded.The perceived pain and the difficulties of the procedure were registered on a dedicated VAS scale immediately (time 1) and 20 minutes after the first injection (time 20).Also, we evaluated the occurrence of occasional adverse events during such procedure and we assessed the perceived difficulty by the doctor administering with such method.RESULTS 39 patients, aged 5-18 years, were recruited and assessed.All patients completed the study, which involved 468 grass pollen AIT SCIT doses, of which 234 with needleless device.At time 1, the use of the needleless device led to an 88% reduction of the pain perception average rate (from 16,8 to 1,97).The difficulty for the technician to make the inoculum was also analyzed (expressed by an increasing rate, from 0 to 4).In all 6 doses, for each child, the difficulty rate 2 relates to an almost constant number of patients, while the highest difficulty rates (grade 3 and grade 4) gradually decrease (until they disappear). CONCLUSIONSThe vaccine administration with needleless device has various advantages and it ensures a better acceptance in comparison with administration by traditional SCIT.This is important in order to start the immunotherapy at an early stage, as it is recommended by the most recent studies, so that the natural evolution of the allergic disease can be immediately modified.The new technique ensures a higher safety both for the vaccinator and for the patient, with a better acceptance of the procedure by the patient and therefore a better and wider compliance to the vaccination schedules.